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Y0001295

螺内酯

Name: 螺内酯
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

4-孕烷-21-油酸-17α-醇-3-酮-7α-硫醇γ-内酯7-乙酸盐, 7α-(乙酰硫基)-17α-羟基-3-氧杂戊烯-4-烯-21-羧酸γ-内酯

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关于此项目

经验公式（希尔记法）:

C₂₄H₃₂O₄S

化学文摘社编号:

52-01-7

分子量:

416.57

NACRES:

NA.24

PubChem Substance ID:

329831347

UNSPSC Code:

41116107

MDL number:

MFCD00082250

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属性

grade

pharmaceutical primary standard

API family

spironolactone

manufacturer/tradename

EDQM

mp

207-208 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13

InChI

1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

InChI key

LXMSZDCAJNLERA-ZHYRCANASA-N

Gene Information

human ... NR3C2(4306)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Spironolactone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

螺内酯是竞争性醛固酮受体拮抗剂。用作保钾利尿剂。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2 - Repr. 1B - STOT RE 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Spironolactone: an old friend rediscovered.

Domenic A Sica

Journal of clinical hypertension (Greenwich, Conn.), 8(7), 467-469 (2006-07-20)

Well tolerated spironolactone-related hyponatremia.

Joel Handler

Journal of clinical hypertension (Greenwich, Conn.), 10(4), 317-321 (2008-04-11)

Effects of spironolactone on long-term mortality and morbidity in patients with heart failure and mild or no symptoms.

Enrico Vizzardi et al.

The American journal of the medical sciences, 347(4), 271-276 (2013-11-08)

The purpose of this study is to evaluate long-term effects of spironolactone, an affordable and widely used aldosterone receptor blocker, in patients with heart failure (HF) and mild or no symptoms. The study is a single-blind, placebo-controlled, blinded endpoint, randomized

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货号	GTIN
Y0001295	04061833797525