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关于此项目
经验公式（希尔记法）:
C45H94N3O19P3
化学文摘社编号:
分子量:
1074.16
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
PI (3,4) P2：18:1, 1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850153P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850153P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 850153P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
General description
18:1 PI（3,4）P2（1，2-二油酰基-sn-甘油-3-磷酸-（1′-肌醇-3′,4′-二磷酸））是修饰脂质的铵盐。
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。
Application
18:1 PI（3,4）P2（1，2-二油酰基-sn-甘油-3-磷酸-（1′-肌醇-3′,4′-二磷酸）（铵盐））已用于：
- 脂质体/支持的脂质双分子层制备
- 脂质体共沉淀
- 阴离子磷脂脂质体的制备
Biochem/physiol Actions
PI（3，4）P2可以充当脂质第二信使。在肥大细胞中，PI（3，4）P2在Ser473位点的蛋白激酶B（PKB）磷酸化中起关键作用。
Packaging
带塞子和压接盖的2 mL棕色血清瓶（850153P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850153P-500ug）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Kewei Ma et al.
Cellular signalling, 20(4), 684-694 (2008-02-06)
The PI3K-PKB pathway is an important and widely studied pathway in cell signaling. The enzyme activity of PI3K produces D-3 phosphoinositides, including the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. PI(3,4,5)P3 has been deemed to be the most important second messenger
Arthur P H de Jong et al.
Neuron, 98(2), 335-349 (2018-04-03)
Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca2+ channels, and the presence of the phospholipid PIP2 in the target membrane. Although the presynaptic active zone mediates the first two requirements, it
Iris K Jarsch et al.
The Journal of cell biology, 219(4) (2020-04-25)
Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are important for cell-cell communication and pathogen internalization. The small size and transient nature of filopodia combined with shared usage of actin regulators within cells confounds attempts to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 850153P-500UG | 04061835229604 |
| 850153P-100UG | 04061835229598 |