T3068
凝血酶产生显色底物
≥90% (HPLC), solid
别名:
β-Ala-Gly-Arg-p-硝基苯胺二乙酸酯
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关于此项目
Form:
solid
Assay:
≥90% (HPLC)
Biological source:
synthetic (organic)
biological source
synthetic (organic)
Quality Level
assay
≥90% (HPLC)
form
solid
technique(s)
activity assay: suitable
storage temp.
2-8°C
SMILES string
[N+](=O)([O-])c1ccc(cc1)NC(=O)[C@@H](NC(=O)CNC(=O)CCN)CCCNC(=N)N.OC(=O)C.OC(=O)C
InChI key
PBMJNSQKWBTVOL-GXKRWWSZSA-N
Application
凝血酶产生的显色底物可用于通过适体亲和捕获而产生的显色检测，并通过随后的酶反应用于检测稀释的人血清中的凝血酶。
Biochem/physiol Actions
凝血酶产生的显色底物也被称为β-Ala-Gly-Arg对硝基苯胺，可被人凝血酶蛋白水解切割并产生β-Ala-Gly-Arg和对硝基苯胺。 对硝基苯胺的释放进行定量后可评估抗凝血酶的活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
实验方案
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。
相关内容
Instructions
D Prasa et al.
Thrombosis and haemostasis, 78(4), 1215-1220 (1997-11-19)
A series of inhibitors of factor Xa (FXa) were investigated using the thrombin generation assay to evaluate the potency and specificity needed to efficiently block thrombin generation in activated human plasma. By inhibiting FXa the generation of thrombin in plasma
Qiang Zhao et al.
Biosensors & bioelectronics, 34(1), 232-237 (2012-03-06)
A simple chromogenic assay for human alpha thrombin is developed through aptamer affinity capture and a subsequent enzyme reaction. Thrombin is captured on the aptamer-modified magnetic beads, and catalyzes the conversion of chromogenic substrates to optically measured products. The measurement
Jan Van Den Abbeele et al.
PLoS pathogens, 6(6), e1000926-e1000926 (2010-06-10)
Tsetse flies are the notorious transmitters of African trypanosomiasis, a disease caused by the Trypanosoma parasite that affects humans and livestock on the African continent. Metacyclic infection rates in natural tsetse populations with Trypanosoma brucei, including the two human-pathogenic subspecies
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T3068-25MG | 04061837343643 |