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Merck
CN

T1637

N-(p-Tosyl)-Gly-Pro-Arg p-nitroanilide acetate salt

thrombin substrate

别名:

N-Tosylglycyl-L-prolyl-L-arginine 4-nitroanilide acetate salt

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关于此项目

线性分子式:
C26H34N8O7S · CH3COOH
化学文摘社编号:
分子量:
662.71
EC Number:
289-285-2
UNSPSC Code:
12352204
PubChem Substance ID:
Beilstein/REAXYS Number:
8891305
MDL number:
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产品名称

N-(p-Tosyl)-Gly-Pro-Arg p-nitroanilide acetate salt, thrombin substrate

InChI key

NGXDRWVTRQRSED-VROPFNGYSA-N

InChI

1S/C26H34N8O7S.C2H4O2/c1-17-6-12-20(13-7-17)42(40,41)30-16-23(35)33-15-3-5-22(33)25(37)32-21(4-2-14-29-26(27)28)24(36)31-18-8-10-19(11-9-18)34(38)39;1-2(3)4/h6-13,21-22,30H,2-5,14-16H2,1H3,(H,31,36)(H,32,37)(H4,27,28,29);1H3,(H,3,4)/t21-,22-;/m0./s1

SMILES string

CC(O)=O.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc3ccc(cc3)[N+]([O-])=O

assay

≥98% (TLC)

form

powder

solubility

ethanol: 20 mg/mL

storage temp.

−20°C

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General description

A chromogenic substrate for thrombin.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

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Qijuan Gu et al.
Pest management science, 77(10), 4730-4740 (2021-06-23)
Parasitic wasps are an important group of entomophagous insects for pest control. As parasitic wasps often lay eggs on or into their associated hosts, parasitoids evolve to utilize several factors including venom, polydnavirus (PDV) to alter host physiology for successful
Rui Nian et al.
Journal of chromatography. A, 1214(1-2), 47-58 (2008-11-14)
Gloshedobin, a recently isolated thrombin-like enzyme from the snake venom of Gloydius shedaoensis, is expressed mainly in the form of inclusion bodies (IBs) in Escherichia coli due to its cysteine-rich nature. Following extraction and solubilization of the IBs, one-step immobilized
Antithrombin (heparin cofactor) assay with "new" chromogenic substrates (S-2238 and Chromozym TH).
U Abildgaard et al.
Thrombosis research, 11(4), 549-553 (1977-10-01)
Qi-Juan Gu et al.
Journal of insect physiology, 116, 41-48 (2019-04-27)
To establish successful infections, endoparasitoid wasps must develop strategies to evade immune responses of the host. Here, we identified and characterized a teratocytes-expressed gene encoding a trypsin inhibitor-like protein containing a cysteine-rich domain from Cotesia vestalis, CvT-TIL. CvT-TIL had a
Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
R Lottenberg et al.
Methods in enzymology, 80 Pt C, 341-361 (1981-01-01)

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