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安全信息

F3379

Sigma-Aldrich

纤维蛋白肽 B 人

≥97% (HPLC)

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W218405-SAMPLE-K
¥657.65
1 KG
¥1,152.37
10 KG
¥3,021.25
20 KG
¥6,699.52

¥657.65

国内现货，预计发货时间2025年4月14日详情

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W218405-SAMPLE-K
¥657.65
1 KG
¥1,152.37
10 KG
¥3,021.25
20 KG
¥6,699.52

About This Item

经验公式（希尔记法）:
C66H93N19O25
CAS号:
36204-23-6
分子量:
1552.56
MDL编号:
MFCD00076439
UNSPSC代码:
12352200
PubChem化学物质编号:
24894841

¥657.65

国内现货，预计发货时间2025年4月14日详情

生物来源

human

方案

≥97% (HPLC)

表单

powder

UniProt登记号

P02675

储存温度

−20°C

SMILES字符串

CC(C)C(NC(=O)CNC(=O)C1CCC(=O)N1)C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NC(Cc2ccccc2)C(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(O)=O

InChI

1S/C66H93N19O25/c1-31(2)53(85-49(91)29-73-55(99)35-16-19-47(89)75-35)64(108)83-42(26-46(68)88)61(105)82-43(27-52(96)97)62(106)81-41(25-45(67)87)60(104)78-37(18-21-51(94)95)57(101)77-36(17-20-50(92)93)56(100)72-28-48(90)76-39(23-33-11-6-4-7-12-33)58(102)80-40(24-34-13-8-5-9-14-34)59(103)84-44(30-86)63(107)74-32(3)54(98)79-38(65(109)110)15-10-22-71-66(69)70/h4-9,11-14,31-32,35-44,53,86H,10,15-30H2,1-3H3,(H2,67,87)(H2,68,88)(H,72,100)(H,73,99)(H,74,107)(H,75,89)(H,76,90)(H,77,101)(H,78,104)(H,79,98)(H,80,102)(H,81,106)(H,82,105)(H,83,108)(H,84,103)(H,85,91)(H,92,93)(H,94,95)(H,96,97)(H,109,110)(H4,69,70,71)

InChI key

MYRIFIVQGRMHRF-UHFFFAOYSA-N

基因信息

human ... FGB(2244)

Amino Acid Sequence

Glp-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg

一般描述

Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain. This peptide is composed of 14 amino acids.[1][2]

生化/生理作用

凝血酶对纤维蛋白原作用而连续释放纤维蛋白肽对正常的纤维蛋白聚合至关重要。从纤维蛋白原 Bβ 链上切下纤维蛋白肽 B 可暴露 E 域聚合位点 E(B)，该位点可与血小板、成纤维细胞和内皮细胞相互作用。
Cleavage of fibrinopeptide B from fibrinogen Bβ chains exposes E domain polymerization sites, E(B), that interact with platelets, fibroblasts and endothelial cells.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    SLBP3239V
    SLBJ6717V
    SLBD0733V
    SLBC3451V
    SLBB4532V

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    Heinz Nika et al.
    Journal of biomolecular techniques : JBT, 24(1), 17-31 (2013-04-02)
    A sample preparation method for protein C-terminal peptide isolation has been developed. In this strategy, protein carboxylate glycinamidation was preceded by carboxyamidomethylation and optional α- and ϵ-amine acetylation in a one-pot reaction, followed by tryptic digestion of the modified protein.
    A Vindigni et al.
    Biochemistry, 35(14), 4417-4426 (1996-04-09)
    The release of fibrinopeptides A and B by the slow and fast forms of thrombin was studied over the temperature range from 5 to 45 degrees C and the salt concentration range from 100 to 800 mM. The sequential mechanism
    Bi-Ying Wei et al.
    Journal of chromatography. A, 1217(44), 6927-6931 (2010-09-21)
    Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with selective reaction monitoring (SRM) is a selective and sensitive method for quantitation of peptides. SRM is achieved via MS/MS utilizing collision-induced dissociation (CID) while monitoring unique precursor-product ion transitions. Low-energy CID
    Michael L Merchant et al.
    Kidney international, 79(5), 546-554 (2010-12-15)
    Biomarkers that evaluate the response to erythropoietic-stimulating agents largely measure inflammation and iron availability. While these are important factors in modifying an individual's response to these agents, they do not address all aspects of a poor response. To clarify this
    T M Odrljin et al.
    Blood, 88(6), 2050-2061 (1996-09-15)
    Thrombin (IIa)-cleavage of fibrinogen (FBG) to form polymerized fibrin promotes endothelial cell spreading, proliferation, and von Willebrand factor release, requiring the exposure of the beta 15-42 domain. Studies reported here indicate that IIa-cleavage of fibrinopeptide B enhances exposure of a
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