所有图片(1)
About This Item
经验公式（希尔记法）:
C31H45N7O7
CAS号:
分子量:
627.73
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
检测方案
≥98% (TLC)
质量水平
形式
powder
溶解性
water: 20 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
Cl.CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C31H45N7O7.ClH/c1-17(2)25(37-30(43)45-31(4,5)6)28(42)38-14-8-10-22(38)27(41)36-21(9-7-13-34-29(32)33)26(40)35-19-11-12-20-18(3)15-24(39)44-23(20)16-19;/h11-12,15-17,21-22,25H,7-10,13-14H2,1-6H3,(H,35,40)(H,36,41)(H,37,43)(H4,32,33,34);1H
InChI key
ROQGJTZGLVLVIN-UHFFFAOYSA-N
一般描述
Boc-Val-Pro-Arg-AMC用作人类激肽释放素8的合成底物。
应用
Boc-Val-Pro-Arg-7-氨基-4-甲基香豆素盐酸盐已被用于
- 在唾液蛋白cE5抑制试验中作为凝血酶的荧光底物
- 作为凝血酶荧光底物的重组E. nipponicum丝氨酸蛋白酶抑制剂抑制试验
- 作为血淋巴蛋白蛋白酶测定的底物
包装
无底玻璃瓶。内含物装在锥底内插管中。
底物
一种用于凝血酶的荧光底物。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Luciano Pirone et al.
The Journal of biological chemistry, 292(30), 12632-12642 (2017-06-09)
Saliva of blood-feeding arthropods carries several antihemostatic compounds whose physiological role is to facilitate successful acquisition of blood. The identification of novel natural anticoagulants and the understanding of their mechanism of action may offer opportunities for designing new antithrombotics disrupting
Tadaaki Kishi et al.
Biological chemistry, 387(6), 723-731 (2006-06-28)
Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activated with lysyl
Jantiwan Sutthangkul et al.
The Journal of biological chemistry, 290(10), 6470-6481 (2015-01-13)
The melanization cascade, activated by the prophenoloxidase (proPO) system, plays a key role in the production of cytotoxic intermediates, as well as melanin products for microbial sequestration in invertebrates. Here, we show that the proPO system is an important component
Pavel Roudnický et al.
Parasite (Paris, France), 25, 61-61 (2018-12-06)
Serpins are a superfamily of serine peptidase inhibitors that participate in the regulation of many physiological and cell peptidase-mediated processes in all organisms (e.g. in blood clotting, complement activation, fibrinolysis, inflammation, and programmed cell death). It was postulated that in
T Morita et al.
Journal of biochemistry, 82(5), 1495-1498 (1977-11-01)
Twenty peptide-4-methylcoumarin amides (MCA) were newly synthesized and tested as possible substrates for alpha-thrombin, factor Xa, kallikreins, urokinase, and plasmin. These fluorogenic peptides contained arginine-MCA as the carboxyl-terminus. Release of 7-amino-4-methylcoumarin was determined fluorometrically. Of these peptides, the following were
实验方案
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。
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