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Merck
CN

G2417

甲磺酸加贝酯

analytical standard, for drug analysis

别名:

4-(6-胍基己酰氧基)苯甲酸乙酯甲磺酸盐, 4-[[6-[(氨基亚氨基甲基)氨基]-1-氧己基]氧]苯甲酸乙酯 甲磺酸盐, 福耶

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关于此项目

经验公式（希尔记法）:
C16H23N3O4 · CH4O3S
化学文摘社编号:
56974-61-9
分子量:
417.48
NACRES:
NA.24
PubChem Substance ID:
329799903
UNSPSC Code:
41116107
MDL number:
MFCD00210299

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产品名称

甲磺酸加贝酯, analytical standard, for drug analysis

InChI key

DNTNDFLIKUKKOC-UHFFFAOYSA-N

SMILES string

CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1

InChI

1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases, which finds therapeutic applications in the treatment of disseminated intravascular coagulation and pancreatitis. It also plays the role of an anticoagulant in hemodialysis therapy.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Giovanni Brandi et al.
PloS one, 7(7), e41347-e41347 (2012-08-23)
The employment of anti-epidermal growth factor receptor (EGFR) antibodies represents a backbone of the therapeutic options for the treatment of metastatic colorectal cancer (mCRC). However, this therapy is poorly effective or ineffective in unselected patients. Mutations in KRAS, BRAF and
Manabu Hayata et al.
American journal of physiology. Renal physiology, 303(8), F1126-F1135 (2012-07-27)
The number of the chronic renal failure (CRF) patients is increasing explosively. Hypertension, proteinuria, inflammation, fibrosis, and oxidative stress are intertwined in a complicated manner that leads to the progression of CRF. However, the therapeutic strategies to delay its progression
Myung Jin Oh et al.
Scandinavian journal of gastroenterology, 47(8-9), 1071-1077 (2012-09-01)
Although endoscopic papillary large balloon dilation (EPLBD) with limited endoscopic sphincterotomy (ES) showed excellent outcomes for treatment of large bile duct stones, hemorrhage and recurrence of stones are problematic complications. Recent studies suggest that EPLBD alone is safe and effective
Dalya M Lateef et al.
Peptides, 32(6), 1289-1295 (2011-04-02)
Camostat mesilate (or mesylate) releases endogenous cholecystokinin (CCK) or CCK-58, the only detectable endocrine form of CCK in the rat, and reduces cumulative food intake by activating CCK(1) receptor. However, the literature lacks meal pattern analysis and an appropriate dose-response
Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug.
Erba F, et al.
Biochemical Pharmacology, 61(3), 271-276 (2001)
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商品

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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