TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
别名:
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
物种:
Human TNFSF11 (8600), Mouse Tnfsf11 (21943), Rat Tnfsf11 (117516), domestic guinea pig Tnfsf11 (100713226), dog TNFSF11 (609418), cow TNFSF11 (513836), naked mole-rat Tnfsf11 (101696350), chicken TNFSF11 (428067), Zebrafish tnfsf11 (100331628)
UniProtKB ID:
基因ID:
- Human(8600) Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
- Mouse(21943) tumor necrosis factor (ligand) superfamily, member 11
- Rat(117516) tumor necrosis factor (ligand) superfamily, member 11
- domestic guinea pig(100713226) tumor necrosis factor (ligand) superfamily, member 11
- dog(609418) tumor necrosis factor (ligand) superfamily, member 11
- cow(513836) tumor necrosis factor (ligand) superfamily, member 11
- naked mole-rat(101696350) tumor necrosis factor (ligand) superfamily, member 11
- chicken(428067) tumor necrosis factor (ligand) superfamily, member 11
- Zebrafish(100331628) tumor necrosis factor (ligand) superfamily, member 11
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Antibodies
产品编号
说明
物种反应性
应用
抗-RANKL抗体（克隆6A12.1）, clone 6A12.1, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-RANKL/TNFSF11 Antibody, clone 1H17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
bovine, human, monkey, porcine
应用
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-RANKL (CD254) Antibody, clone IK22-5, ,
物种反应性
mouse
应用
flow cytometry
immunofluorescence
immunohistochemistry
neutralization
immunofluorescence
immunohistochemistry
neutralization
Anti-TNFSF11 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-TNFSF11 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Proteins
产品编号
说明
物种
RANK 配体 来源于小鼠, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture,
物种
mouse
sRANKL 人, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
物种
human
RANK Ligand/TRANCE human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
物种
human
可溶性 RANK 配体 (sRANKL) 蛋白，重组人, The recombinant human sRANKL protein is produced in E. Coli.,
物种
human
esiRNA
产品编号
说明
物种