PILRA
paired immunoglobin-like type 2 receptor alpha
FDF03
Human PILRA (29992), Mouse Pilra (231805), Rat Pilra (288568), dog PILRA (489841), domestic guinea pig Pilra (100715696), sheep PILRA (101122158), naked mole-rat Pilra (101721193), cow PILRA (100137734)
- Human(29992) Summary: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
- Mouse(231805) paired immunoglobin-like type 2 receptor alpha
- Rat(288568) paired immunoglobin-like type 2 receptor alpha
- dog(489841) paired immunoglobin-like type 2 receptor alpha
- domestic guinea pig(100715696) paired immunoglobin-like type 2 receptor alpha
- sheep(101122158) paired immunoglobin-like type 2 receptor alpha
- naked mole-rat(101721193) paired immunoglobin-like type 2 receptor alpha
- cow(100137734) paired immunoglobin-like type 2 receptor alpha
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Antibodies
Anti-PILRA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
human
immunohistochemistry
Monoclonal Anti-PILRA antibody produced in mouse, clone 3C2, purified immunoglobulin, buffered aqueous solution,
human
ELISA
western blot
western blot