NCF4
neutrophil cytosolic factor 4, 40kDa
别名:
NCF, P40PHOX, SH3PXD4
物种:
Human NCF4 (4689), Mouse Ncf4 (17972), Rat Ncf4 (500904), chicken NCF4 (418052), Zebrafish ncf4 (403014), domestic cat NCF4 (101095507), dog NCF4 (481277), cow NCF4 (507859), Horse NCF4 (100069566), sheep NCF4 (101122939) ...展开
UniProtKB ID:
基因ID:
- Human(4689) Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(17972) neutrophil cytosolic factor 4
- Rat(500904) neutrophil cytosolic factor 4
- chicken(418052) neutrophil cytosolic factor 4, 40kDa
- Zebrafish(403014) neutrophil cytosolic factor 4
- domestic cat(101095507) neutrophil cytosolic factor 4, 40kDa
- dog(481277) neutrophil cytosolic factor 4, 40kDa
- cow(507859) neutrophil cytosolic factor 4, 40kDa
- Horse(100069566) neutrophil cytosolic factor 4, 40kDa
- sheep(101122939) neutrophil cytosolic factor 4, 40kDa
- Domestic Rabbit(100009359) neutrophil cytosolic factor 4, 40kDa
- domestic guinea pig(100729267) neutrophil cytosolic factor 4, 40kDa
- naked mole-rat(101699188) neutrophil cytosolic factor 4, 40kDa
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Antibodies
货号
说明
物种反应性
应用
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
Monoclonal Anti-NCF4 antibody produced in mouse, clone 3C10, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
Anti-NCF4/p40-phox Antibody, clone 4L9Z4, Rabbit Monoclonal, ,
物种反应性
mouse
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Phospho-NCF4-T154 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
western blot
Anti-NCF4 antibody produced in rabbit, affinity isolated antibody,
物种反应性
guinea pig, horse, human, rat
应用
western blot
Proteins
货号
说明
物种