LIMK2
LIM domain kinase 2
别名:
物种:
Human LIMK2 (3985), Mouse Limk2 (16886), Rat Limk2 (29524), dog LIMK2 (486363), chicken LIMK2 (396010), Zebrafish limk2 (436924), naked mole-rat Limk2 (101698063), sheep LIMK2 (101114815), Horse LIMK2 (100058419), cow LIMK2 (513539) ...展开
UniProtKB ID:
基因ID:
- Human(3985) Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(16886) LIM motif-containing protein kinase 2
- Rat(29524) LIM domain kinase 2
- dog(486363) LIM domain kinase 2
- chicken(396010) LIM domain kinase 2
- Zebrafish(436924) LIM domain kinase 2
- naked mole-rat(101698063) LIM domain kinase 2
- sheep(101114815) LIM domain kinase 2
- Horse(100058419) LIM domain kinase 2
- cow(513539) LIM domain kinase 2
- domestic cat(101096766) LIM domain kinase 2
- domestic guinea pig(100720658) LIM domain kinase 2
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Antibodies
货号
说明
物种反应性
应用
Anti-phospho-LIMK2 (pThr505) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LIMK2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-phospho-LIMK2 (pThr505) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LIMK2 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-LIMK2 antibody produced in mouse, clone 2H2-E11, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Proteins
货号
说明
物种
esiRNA
货号
说明
物种