LATS1
large tumor suppressor kinase 1
别名:
WARTS, wts
物种:
Human LATS1 (9113), Mouse Lats1 (16798), Rat Lats1 (308265), Domestic Rabbit LATS1 (100341222), domestic cat LATS1 (101081470), Horse LATS1 (100060397), dog LATS1 (476241), chicken LATS1 (421627), Zebrafish lats1 (553164), naked mole-rat Lats1 (101725200) ...展开
UniProtKB ID:
基因ID:
- Human(9113) Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]
- Mouse(16798) large tumor suppressor
- Rat(308265) large tumor suppressor kinase 1
- Domestic Rabbit(100341222) LATS, large tumor suppressor, homolog 1 (Drosophila)
- domestic cat(101081470) LATS, large tumor suppressor, homolog 1 (Drosophila)
- Horse(100060397) LATS, large tumor suppressor, homolog 1 (Drosophila)
- dog(476241) LATS, large tumor suppressor, homolog 1 (Drosophila)
- chicken(421627) LATS, large tumor suppressor, homolog 1 (Drosophila)
- Zebrafish(553164) LATS, large tumor suppressor, homolog 1 (Drosophila)
- naked mole-rat(101725200) large tumor suppressor kinase 1
- domestic guinea pig(100716806) large tumor suppressor kinase 1
- cow(535935) LATS, large tumor suppressor, homolog 1 (Drosophila)
- sheep(101122867) LATS, large tumor suppressor, homolog 1 (Drosophila)
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Antibodies
货号
说明
物种反应性
应用
Anti-LATS1 (N-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LATS1 Antibody, clone 1D18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse
应用
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LATS1 Antibody, clone 9A3.1, clone 9A3.1, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-LATS1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
ELISA
immunohistochemistry
immunohistochemistry
Monoclonal Anti-LATS1 antibody produced in mouse, clone 3A7, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
Proteins
货号
说明
物种
LATS1，活性，GST 标记 人, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
esiRNA
货号
说明
物种