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Merck
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HLA-A

major histocompatibility complex, class I, A

别名:
HLAA
物种:
Human HLA-A (3105)
UniProtKB ID:
P16190, O02939, O02954
基因ID:
  • Human(3105) Summary: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

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Antibodies

货号
说明
物种反应性
应用
SAB1405936
Anti-HLA-A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
flow cytometry
western blot
MAB1275
Anti-HLA-ABC Common Antibody, clone 22.63.4, clone 22.63.4, Chemicon®, from mouse,
物种反应性
human
应用
flow cytometry
immunocytochemistry
immunohistochemistry
SAB4700298
Monoclonal Anti-HLA-A2 azide free antibody produced in mouse, clone BB7.2, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
flow cytometry
immunoprecipitation (IP)
SAB4700834
Monoclonal Anti-HLAClass I antibody produced in mouse, clone W6/32,
物种反应性
bovine, cat, human, nonhuman primates
应用
western blot
ZRB2491
Anti-HLA-A Antibody, clone 2K7 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human
应用
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot