HAAO
3-hydroxyanthranilate 3,4-dioxygenase
别名:
3-HAO, HAO
物种:
Human HAAO (23498), Mouse Haao (107766), Rat Haao (56823), Zebrafish haao (492518), sheep HAAO (101115197), chicken HAAO (421396), dog HAAO (611728), domestic guinea pig Haao (100718413), cow HAAO (510602), domestic cat HAAO (101092928)
UniProtKB ID:
基因ID:
- Human(23498) Summary: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
- Mouse(107766) 3-hydroxyanthranilate 3,4-dioxygenase
- Rat(56823) 3-hydroxyanthranilate 3,4-dioxygenase
- Zebrafish(492518) 3-hydroxyanthranilate 3,4-dioxygenase
- sheep(101115197) 3-hydroxyanthranilate 3,4-dioxygenase
- chicken(421396) 3-hydroxyanthranilate 3,4-dioxygenase
- dog(611728) 3-hydroxyanthranilate 3,4-dioxygenase
- domestic guinea pig(100718413) 3-hydroxyanthranilate 3,4-dioxygenase
- cow(510602) 3-hydroxyanthranilate 3,4-dioxygenase
- domestic cat(101092928) 3-hydroxyanthranilate 3,4-dioxygenase
- naked mole-rat(101717713) 3-hydroxyanthranilate 3,4-dioxygenase
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Antibodies
货号
说明
物种反应性
应用
Anti-HAAO antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-HAAO antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-HAAO antibody produced in mouse, clone 4D1, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
Anti-HAAO antibody produced in rabbit, affinity isolated antibody,
物种反应性
guinea pig, horse, human, mouse, rabbit, rat
应用
western blot