FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
别名:
AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
物种:
Human FBXW7 (55294), Mouse Fbxw7 (50754), Rat Fbxw7 (100360914), domestic guinea pig Fbxw7 (100734383), naked mole-rat Fbxw7 (101717987), Zebrafish fbxw7 (564991), sheep FBXW7 (101104688), dog FBXW7 (475465), Horse FBXW7 (100062294), domestic cat FBXW7 (101096146) ...展开
UniProtKB ID:
基因ID:
- Human(55294) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
- Mouse(50754) F-box and WD-40 domain protein 7
- Rat(100360914) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
- domestic guinea pig(100734383) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
- naked mole-rat(101717987) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
- Zebrafish(564991) F-box and WD repeat domain containing 7
- sheep(101104688) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
- dog(475465) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
- Horse(100062294) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
- domestic cat(101096146) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
- cow(540932) F-box and WD repeat domain containing 7
- chicken(422481) F-box and WD repeat domain containing 7
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Antibodies
货号
说明
物种反应性
应用
Monoclonal Anti-FBXW7 antibody produced in mouse, clone 3D1, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Cdc4 (FBXW7) Antibody, clone 9D8.1, clone 9D8.1, from mouse,
物种反应性
human, mouse
应用
western blot
Anti-FBXW7 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP237, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-F-box/WD repeat-containing protein 7 Antibody, from rabbit, purified by affinity chromatography,
物种反应性
bovine, canine, feline, gorilla, horse, human, porcine, rhesus macaque
应用
immunohistochemistry
western blot
western blot