DCTN1
dynactin 1
别名:
DAP-150, DP-150, P135
物种:
Human DCTN1 (1639), Mouse Dctn1 (13191), Rat Dctn1 (29167), naked mole-rat Dctn1 (101703706), domestic guinea pig Dctn1 (100714202), Domestic Rabbit DCTN1 (100346609), sheep DCTN1 (101116037), cow DCTN1 (511045), domestic cat DCTN1 (101084533), Horse DCTN1 (100053938) ...展开
UniProtKB ID:
基因ID:
- Human(1639) Summary: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
- Mouse(13191) dynactin 1
- Rat(29167) dynactin 1
- naked mole-rat(101703706) dynactin 1
- domestic guinea pig(100714202) dynactin 1
- Domestic Rabbit(100346609) dynactin 1
- sheep(101116037) dynactin 1
- cow(511045) dynactin 1
- domestic cat(101084533) dynactin 1
- Horse(100053938) dynactin 1
- dog(483106) dynactin 1
- chicken(426238) dynactin 1
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Antibodies
货号
说明
物种反应性
应用
Anti-Dctn1 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-DCTN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
Anti-DCTN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-DCTN1 antibody produced in mouse, clone 1E12, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
Monoclonal Anti-DCTN1 antibody produced in mouse, clone 2E4-1C2, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
esiRNA
货号
说明
物种