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O6503

L-Ornithine monohydrochloride

Name: <SC>L</SC>-Ornithine monohydrochloride
Brand: SIGMA

BioReagent, suitable for cell culture, ≥99%

Synonym(s):

(S)-2,5-Diaminopentanoic acid monohydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₅H₁₂N₂O₂ · HCl

CAS Number:

3184-13-2

Molecular Weight:

168.62

Beilstein:

3625847

EC Number:

221-678-6

MDL number:

MFCD00064562

UNSPSC Code:

12352209

PubChem Substance ID:

24898036

NACRES:

NA.75

biological source

microbial

Quality Level

200

product line

BioReagent

Assay

≥99%

form

powder

packaging

pkg of 100 g
pkg of 25 g

technique(s)

cell culture | mammalian: suitable

impurities

ammonia and citrulline, essentially free

solubility

H₂O: soluble 50 mg/mL, clear, colorless to very faintly yellow

SMILES string

Cl.NCCC[C@H](N)C(O)=O

InChI

1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1

InChI key

GGTYBZJRPHEQDG-WCCKRBBISA-N

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General description

L-Ornithine is the functional metabolite of L-arginine.

L-Ornithine is an amino acid that is not coded for by the genetic code. It is formed during the decomposition of argininine by arginase and participates in the urea cycle. Ornithine is the starting point for the formation of a family of polyamines that include spermine, spermidine and putrescine.

Application

L-Ornithine monohydrochloride has been used:

as a supplement in Dulbecco′s modified eagle medium (DMEM) for cell growth assays
as a component in the standard medium for primary human hepatocytes (PHH) culture
as a creatine synthesis inhibitor

Biochem/physiol Actions

L-ornithine acts as a precursor for polyamines. It may modulate the intake of food as an acute satiety signal in the neonatal chick brain.

L-Ornithine is used as a media supplement to support the biosynthesis of polyamines.

Other Notes

Product of arginine degradation by arginase

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Arginine

Profiles of Drug Substances, Excipients, and Related Methodology, 27, 1-32 (2001)

L-Ornithine is a potential acute satiety signal in the brain of neonatal chicks

Tran PV, et al.

Physiology & Behavior, 155, 141-148 (2016)

Polyamines and their derivatives as modulators in growth and differentiation.

Z N Canellakis et al.

The Yale journal of biology and medicine, 62(5), 481-491 (1989-09-01)

The polyamines and their derivatives are essential for life in eukaryotic and most prokaryotic cells, but their exact role in preserving cell function is not clear. These polyamines provide endogenous cations and thus participate in regulation of the intracellular pH;

Arginase 2 suppresses renal carcinoma progression via biosynthetic cofactor pyridoxal phosphate depletion and increased polyamine toxicity

Ochocki JD, et al.

Cell Metabolism, 27(6), 1263-1280 (2018)

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

Ji L, et al.

Immunity, 51(2), 272-284 (2019)

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Articles

L-Ornithine in Cell Culture

Discover L-ornithine, an important amino acid supplement, explore how L-ornithine is used in CHO and iPSC culture, and discover how poly-L-ornithine is used to enhance cell attachment.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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