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Safety Information

M9766

Sigma-Aldrich

4-Methylumbelliferyl α-D-glucopyranoside

α-glucosidase substrate, fluorogenic, ≥99% (TLC), powder

Synonym(s):

4-Methylumbelliferyl α-D-glucoside

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About This Item

Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
17833-43-1
Molecular Weight:
338.31
Beilstein:
1690776
EC Number:
241-794-0
MDL number:
MFCD00067661
UNSPSC Code:
12352204
PubChem Substance ID:
24897365
NACRES:
NA.32
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Product Name

4-Methylumbelliferyl α-D-glucopyranoside, α-glucosidase substrate

Quality Level

300

description

α-glucosidase substrate

Assay

≥99% (TLC)

form

powder

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1

InChI key

YUDPTGPSBJVHCN-JZYAIQKZSA-N

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Show Differences

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This Item
M0905M9659M7008
4-Methylumbelliferyl α-D-glucopyranoside α-glucosidase substrate

M9766

4-Methylumbelliferyl α-D-glucopyranoside

4-Methylumbelliferyl β-D-mannopyranoside ≥98% (TLC)

M0905

4-Methylumbelliferyl β-D-mannopyranoside

4-Methylumbelliferyl N-acetyl-β-D-galactosaminide ≥98% (HPLC)

M9659

4-Methylumbelliferyl N-acetyl-β-D-galactosaminide

4-Methylumbelliferyl-β-D-xylopyranoside β-xylosidase substrate

M7008

4-Methylumbelliferyl-β-D-xylopyranoside

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

solubility

pyridine: 10 mg/mL, clear, colorless to faintly yellow

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

description

α-glucosidase substrate

description

-

description

-

description

-

Application

4-Methylumbelliferyl ǥ-D-glucopyranoside has been used to assay acid alpha-glucosidase (GAA) activity in tissue homogenates.[1][1][2]

Biochem/physiol Actions

4-Methylumbelliferyl ǥ-D-glucopyranoside serves as a fluorogenic substrate for the ǥ-glucosidase enzyme. The product, 4-methylumbelliferyl, shows a peak at 440nm in the fluorescence spectra.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000424209
    0000424208
    0000424207
    0000424207
    0000424208

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    Omid Motabar et al.
    Analytical biochemistry, 390(1), 79-84 (2009-04-18)
    Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic
    Darin J Falk et al.
    Molecular therapy : the journal of the American Society of Gene Therapy, 21(9), 1661-1667 (2013-06-05)
    Pompe disease is a neuromuscular disease resulting from deficiency in acid α-glucosidase (GAA), results in cardiac, skeletal muscle, and central nervous system (CNS) pathology. Enzyme replacement therapy (ERT) has been shown to partially correct cardiac and skeletal muscle dysfunction. However
    Phillip A Doerfler et al.
    Human gene therapy, 27(1), 43-59 (2015-11-26)
    Pompe disease is a progressive neuromuscular disorder caused by lysosomal accumulation of glycogen from a deficiency in acid alpha-glucosidase (GAA). Replacement of the missing enzyme is available by repeated protein infusions; however, efficacy is limited by immune response and inability
    Ryoga Hamura et al.
    Cancer science, 112(6), 2335-2348 (2021-05-02)
    Lysosomal degradation plays a crucial role in the metabolism of biological macromolecules supplied by autophagy. The regulation of the autophagy-lysosome system, which contributes to intracellular homeostasis, chemoresistance, and tumor progression, has recently been revealed as a promising therapeutic approach for
    J E Magyar et al.
    The international journal of biochemistry & cell biology, 41(3), 694-700 (2008-09-04)
    It has been recently reported that tea flavanols, including epigallocatechin gallate (EGCG), efficiently inhibit glucosidase II in liver microsomes. Since glucosidase II plays a central role in glycoprotein processing and quality control in the endoplasmic reticulum we investigated the possible
    View All Related Papers

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