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A8980

Sigma-Aldrich

Acarbose

≥95% (HPLC)

Synonym(s):

4",6"-Dideoxy-4"-([1S]-[1,4,6/5]-4,5,6-trihydroxy-3-hydroxymethyl-2-yclohexenylamino)-maltotriose

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1 G
CN¥1,881.26

CN¥1,881.26

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1 G
CN¥1,881.26

About This Item

Empirical Formula (Hill Notation):
C25H43NO18
CAS Number:
56180-94-0
Molecular Weight:
645.60
EC Number:
260-030-7
MDL number:
MFCD00869592
UNSPSC Code:
12352201
PubChem Substance ID:
329771024
NACRES:
NA.25

CN¥1,881.26

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Request a Bulk Order

biological source

bacterial (Actinoplanes)

Quality Level

200

Assay

≥95% (HPLC)

form

powder

impurities

<9.4% water (Karl Fischer)

color

white to off-white

solubility

H2O (CO2 free): 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O[C@@H]2CO)O[C@H]3[C@H](O)[C@@H](O)[C@H](O)O[C@@H]3CO)[C@H](O)[C@@H](O)[C@@H]1N[C@H]4C=C(CO)[C@@H](O)[C@H](O)[C@H]4O

InChI

1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1

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Show Differences

1 of 4

This Item
C9008H6904H1252
Acarbose &#8805;95% (HPLC)

A8980

Acarbose

p-Coumaric acid &#8805;98.0% (HPLC)

C9008

p-Coumaric acid

6&#946;-Hydroxycortisol &#8805;98%

H6904

6β-Hydroxycortisol

Homovanillic acid Fluorimetric reagent

H1252

Homovanillic acid

assay

≥95% (HPLC)

assay

≥98.0% (HPLC)

assay

≥98%

assay

>99% (TLC)

solubility

H2O (CO2 free): 50 mg/mL, clear, colorless

solubility

ethanol: 50 mg/mL

solubility

methanol: 50 mg/mL, clear, colorless

solubility

ethanol: 50 mg/mL, colorless to light yellow

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

Application

Acarbose, a derivitized maltotriose antidiabetic drug, is a reversible α-glucosidase inhibitor used in medical studies to control the effects of Type II diabetes. Acarbose is often used as a reference to which other α-glucosidase inhibitors are compared.

Biochem/physiol Actions

Modified tetrasaccharide that acts as a reversible α -glucosidase inhibitor.

Other Notes

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000410797
    0000364921
    0000410797
    WXBF4600V
    0000364921

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    Patrick Schwientek et al.
    BMC genomics, 13, 112-112 (2012-03-27)
    Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase inhibitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. As the incidence of diabetes is rapidly rising worldwide, an ever increasing demand
    Ashley S Boath et al.
    Food chemistry, 135(3), 929-936 (2012-09-08)
    Polyphenol-rich extracts from certain berries inhibited α-glucosidase activity in vitro. The two most effective berry extracts, from black currant and rowanberry, inhibited α-glucosidase with IC(50) values respectively of 20 and 30μg GAE/ml and were as effective as the pharmaceutical inhibitor
    Alessandro Leone et al.
    Nutrients, 10(10) (2018-10-17)
    The hypoglycemic effect in humans of Moringa oleifera (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and
    Muhammad Jihad Sandikapura et al.
    Pakistan journal of pharmaceutical sciences, 31(2(Suppl.)), 623-635 (2018-04-08)
    The study was aimed to perform aqueous extraction of two plants using different extraction methods, and evaluate their antioxidant and antidiabetic potential. Plant materials were extracted by maceration, soxhlet, sonication and fresh juice methods to produce aqueous extracts. In vitro
    Ranee Singh et al.
    Journal of feline medicine and surgery, 17(10), 848-857 (2014-10-26)
    Feeding a low carbohydrate diet is recommended for diabetic cats; however, some cats may require diets containing moderate-to-high carbohydrate and may benefit from the use of therapeutic agents to improve glycemic control. The aim of the study was to determine
    View All Related Papers

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