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Safety Information

69591

Sigma-Aldrich

4-Methylumbelliferyl α-D-glucopyranoside

≥98% (TLC)

Synonym(s):

4-Methylumbelliferyl α-D-glucoside

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100 ML
¥458.16
500 ML
¥368.78
1 L
¥944.34
4 L
¥3,305.18

¥458.16

Available to ship on2025年4月17日Details

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100 ML
¥458.16
500 ML
¥368.78
1 L
¥944.34
4 L
¥3,305.18

About This Item

Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
17833-43-1
Molecular Weight:
338.31
Beilstein:
1690776
EC Number:
241-794-0
MDL number:
MFCD00067661
UNSPSC Code:
12352204
PubChem Substance ID:
57652200
NACRES:
NA.25

¥458.16

Available to ship on2025年4月17日Details

Request a Bulk Order

description

α-glucosidase substrate

Quality Level

200

Assay

≥98% (TLC)

form

powder

solubility

DMSO: 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λex 316 nm; λem 375 nm (Reaction product)
λex 317 nm; λem 374 nm (pH9.0)
λex 360 nm; λem 449 nm
λex 365 nm; λem 445 nm in 0.1 M Tris pH 8.0 (α-glucosidase)

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1

InChI key

YUDPTGPSBJVHCN-JZYAIQKZSA-N

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G901249767G6279
甘油 for molecular biology, ≥99.0%

G5516

甘油

甘油 ≥99.5%

G9012

甘油

甘油 BioUltra, anhydrous, ≥99.5% (GC)

49767

甘油

甘油 BioXtra, ≥99% (GC)

G6279

甘油

application(s)

life science and biopharma
microbiology
sample preservation

application(s)

lipidomics
liquid formulation
sample preservation

application(s)

-

application(s)

-

technique(s)

MALDI-MS: suitable, cryopreservation: suitable

technique(s)

immunofluorescence: suitable

technique(s)

-

technique(s)

-

grade

for molecular biology, reagent

grade

-

grade

for molecular biology

grade

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

water: 1 mL/mL, clear, colorless

solubility

water: 1 mL/mL, clear, colorless to faintly yellow

solubility

H2O: 5 M at 20 °C, clear, colorless

solubility

-

General description

4-Methylumbelliferyl α-D-glucopyranoside is the fluorogenic substrate of alpha-glucosidase enzyme.[1] 4-Methylumbelliferyl α-D-glucopyranoside, also known as 4MU- α-glc, upon reaction leads to the product 4MU, which emits at the peak of 440nm in the fluorescence spectra.[2]

Application

4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s).[3]4-Methylumbelliferyl α-D-glucopyranoside is used for high throughput screening experiments. It is suitable for the diagnosis of Pompe′s disease in kidney and leucocytes.[4]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000424185
    0000424184
    0000424206
    0000424184
    0000424206

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    Blanca I Torres-Rodríguez et al.
    Antonie van Leeuwenhoek, 101(2), 313-322 (2011-09-20)
    The early steps of glycoprotein biosynthesis involve processing of the N-glycan core by endoplasmic reticulum α-glucosidases I and II which sequentially trim the outermost α1,2-linked and the two more internal α1,3-linked glucose units, respectively. We have demonstrated the presence of
    D M Broadhead et al.
    Clinical genetics, 13(6), 504-510 (1978-06-01)
    The diagnosis of Pompe's disease by the assay of acid alpha-glucosidase in kidney and leucocytes was not previously possible because of the presence of another component which had activity at pH 4.0, but was not deficient in the disease. This
    Shohei Shigeto et al.
    Molecular genetics and metabolism, 103(1), 12-17 (2011-02-16)
    The high frequency (3.3-3.9%) of acid α-glucosidase pseudodeficiency, c.[1726G>A; 2065G>A] homozygote (AA homozygote), in Asian populations complicates newborn screening for Pompe disease (glycogen storage disease type II or acid maltase deficiency) on dried blood spots, since AA homozygotes have a
    Reporter bacteriophage A511::celB transduces a hyperthermostable glycosidase from Pyrococcus furiosus for rapid and simple detection of viable Listeria cells.
    Hagens S, de Wouters T, et al.
    Bacteriophages, 1, 143-151 (2011)
    Toshiro Matsui et al.
    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 25(4), 559-562 (2009-04-11)
    Alpha-glucosidase (AGH) from the small intestine of rat was immobilized onto a glutaraldehyde (GA) activated NH(2)-96 well microplate to establish a convenient and rapid AGH inhibition assay system. After AGH immobilization, remaining GA groups were blocked by beta-alanine to induce
    View All Related Papers

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