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Safety Information

H4001

Sigma-Aldrich

Hydrocortisone

≥98% (HPLC)

Synonym(s):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
50-23-7
Molecular Weight:
362.46
Beilstein:
1354819
EC Number:
200-020-1
MDL number:
MFCD00011654
UNSPSC Code:
51111800
PubChem Substance ID:
24278466
NACRES:
NA.77
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biological source

synthetic (organic)

Quality Level

300

sterility

non-sterile

Assay

≥98% (HPLC)

form

powder

mp

211-214 °C (lit.)

solubility

water: 0.28 g/L at 25 °C

application(s)

cell analysis

shipped in

ambient

storage temp.

room temp

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Show Differences

1 of 4

This Item
PHR1014H3160H0135
氢化可的松 ≥98% (HPLC)

H4001

氢化可的松

氢化可的松 Pharmaceutical Secondary Standard; Certified Reference Material

PHR1014

氢化可的松

氢化可的松 meets USP testing specifications

H3160

氢化可的松

氢化可的松 γ-irradiated, powder, BioXtra, suitable for cell culture

H0135

氢化可的松

form

powder

form

-

form

powder

form

powder

assay

≥98% (HPLC)

assay

-

assay

97.0-102.0% dry basis

assay

≥80% (HPLC)

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

200

storage temp.

room temp

storage temp.

2-30°C

storage temp.

-

storage temp.

room temp

solubility

water: 0.28 g/L at 25 °C

solubility

-

solubility

water: soluble 0.28 g/L at 25 °C

solubility

ethanol: 1 mg/mL, clear

shipped in

ambient

shipped in

-

shipped in

-

shipped in

ambient

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360Df,H373

Hazard Classifications

Repr. 1A - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000428954
    0000428954
    0000422285
    0000422285
    0000418312

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    Florian Hardeveld et al.
    Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
    Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
    Rachel Yehuda et al.
    The American journal of psychiatry, 171(8), 872-880 (2014-05-17)
    Differential effects of maternal and paternal posttraumatic stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. The authors examined the relative influences of maternal and paternal PTSD
    Marianne Oksnes et al.
    The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
    Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)
    Liselotte van Bloemendaal et al.
    Diabetes, 63(12), 4186-4196 (2014-07-30)
    Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in
    K J Rademaker et al.
    Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
    The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects
    View All Related Papers

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