biological source
synthetic
Quality Level
assay
≥98.5% (HPLC)
form
powder or crystals
optical activity
[α]20/D +223±3°, c = 1% in ethanol
mp
179-183 °C
functional group
ketone
SMILES string
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Gene Information
human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)
General description
皮质酮 (Cort) 是一种糖皮质激素。也是介导鸟类应激反应的主要激素。是大鼠血浆中主要的肾上腺皮质类固醇。已在小鼠模型中研究了母体皮质酮暴露对发育中胎盘的影响。
Application
皮质酮用于研究大鼠、蜥蜴类或体外研究中的肾上腺素受体信号。还用于免疫抑制实验。
Biochem/physiol Actions
皮质酮由肾上腺皮质中的胆固醇合成,可激活盐皮质激素和糖皮质激素受体。皮质酮的作用是至关重要的生殖过程,包括排卵,黄体,卵母细胞的发展,分娩和哺乳。皮质酮的代谢受 11β-羟基类固醇脱氢酶的调节。
Packaging
无底玻璃瓶。内含物在插入的融合锥内。
Preparation Note
皮质酮可溶于氯仿和乙醇。
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存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
Corticosterone and brood abandonment in a passerine bird.
Ouyang JQ, et al.
Animal behaviour, 84(1), 261-268 (2012)
Stress, corticosterone responses and avian personalities.
Cockrem JF.
Journal of Ornithology, 148(2), 169-178 (2007)
A M Iacopino et al.
The Journal of biological chemistry, 265(18), 10177-10180 (1990-06-25)
Corticosterone was administered to normal and bilaterally adrenalectomized rats (250-300 g), and hormonal regulation of brain calbindin-D28k (CaBP28k) levels was investigated by radioimmunoassay for CaBP28k protein and by slot and Northern blot analyses for CaBP28k mRNA. The specificity of the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 27840-100MG | 04061826203439 |
| 27840-500MG | 04061826203446 |