27840
肾上腺酮
≥98.5% (HPLC)
别名:
11β,21-二羟丙酮-4-孕烯-3,20-二酮, 11β,21-二羟基黄体酮, 4-孕烯-11β,21-二醇-3,20-二酮, Kendall化合物B, Reichstein物质H
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关于此项目
经验公式（希尔记法）:
C21H30O4
化学文摘社编号:
分子量:
346.46
UNSPSC Code:
12352211
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-019-6
Beilstein/REAXYS Number:
2339601
MDL number:
产品名称
肾上腺酮, ≥98.5% (HPLC)
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
SMILES string
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
biological source
synthetic
assay
≥98.5% (HPLC)
form
powder or crystals
optical activity
[α]20/D +223±3°, c = 1% in ethanol
mp
179-183 °C (lit.)
179-183 °C
functional group
ketone
Quality Level
Gene Information
human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)
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Application
皮质酮用于研究大鼠、蜥蜴类或体外研究中的肾上腺素受体信号。还用于免疫抑制实验。
Biochem/physiol Actions
皮质酮由肾上腺皮质中的胆固醇合成，可激活盐皮质激素和糖皮质激素受体。皮质酮的作用是至关重要的生殖过程，包括排卵，黄体，卵母细胞的发展，分娩和哺乳。皮质酮的代谢受 11β-羟基类固醇脱氢酶的调节。
General description
皮质酮 (Cort) 是一种糖皮质激素。也是介导鸟类应激反应的主要激素。是大鼠血浆中主要的肾上腺皮质类固醇。已在小鼠模型中研究了母体皮质酮暴露对发育中胎盘的影响。
Packaging
无底玻璃瓶。内含物在插入的融合锥内。
Preparation Note
皮质酮可溶于氯仿和乙醇。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
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Practical procedure for estimation of corticosterone or hydrocortisone.
R H SILBER et al.
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Amanda J Rickard et al.
Journal of molecular endocrinology, 42(6), 449-459 (2009-01-23)
The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on
A M Iacopino et al.
The Journal of biological chemistry, 265(18), 10177-10180 (1990-06-25)
Corticosterone was administered to normal and bilaterally adrenalectomized rats (250-300 g), and hormonal regulation of brain calbindin-D28k (CaBP28k) levels was investigated by radioimmunoassay for CaBP28k protein and by slot and Northern blot analyses for CaBP28k mRNA. The specificity of the
D F DeNardo et al.
Hormones and behavior, 27(2), 184-199 (1993-06-01)
Adrenal corticoid release is a major component of the stress response which can affect many body functions including behavior. The purpose of our studies was to examine the effects of corticosterone (B) on both the agonistic and courtship components of
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