推荐产品
生物来源
synthetic
质量水平
方案
≥98.5% (HPLC)
表单
powder or crystals
旋光性
[α]20/D +223±3°, c = 1% in ethanol
mp
179-183 °C (lit.)
179-183 °C
官能团
ketone
SMILES字符串
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
基因信息
human ... EBP(10682) , SERPINA6(866)
rat ... Ar(24208) , Nr3c1(24413)
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一般描述
皮质酮 (Cort) 是一种糖皮质激素。也是介导鸟类应激反应的主要激素。是大鼠血浆中主要的肾上腺皮质类固醇。已在小鼠模型中研究了母体皮质酮暴露对发育中胎盘的影响。
应用
皮质酮用于研究大鼠、蜥蜴类或体外研究中的肾上腺素受体信号。还用于免疫抑制实验。
生化/生理作用
皮质酮由肾上腺皮质中的胆固醇合成，可激活盐皮质激素和糖皮质激素受体。皮质酮的作用是至关重要的生殖过程，包括排卵，黄体，卵母细胞的发展，分娩和哺乳。皮质酮的代谢受 11β-羟基类固醇脱氢酶的调节。
包装
无底玻璃瓶。内含物在插入的融合锥内。
制备说明
皮质酮可溶于氯仿和乙醇。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
D F DeNardo et al.
Hormones and behavior, 27(2), 184-199 (1993-06-01)
Adrenal corticoid release is a major component of the stress response which can affect many body functions including behavior. The purpose of our studies was to examine the effects of corticosterone (B) on both the agonistic and courtship components of
Amanda J Rickard et al.
Journal of molecular endocrinology, 42(6), 449-459 (2009-01-23)
The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on
A M Iacopino et al.
The Journal of biological chemistry, 265(18), 10177-10180 (1990-06-25)
Corticosterone was administered to normal and bilaterally adrenalectomized rats (250-300 g), and hormonal regulation of brain calbindin-D28k (CaBP28k) levels was investigated by radioimmunoassay for CaBP28k protein and by slot and Northern blot analyses for CaBP28k mRNA. The specificity of the
Practical procedure for estimation of corticosterone or hydrocortisone.
R H SILBER et al.
Clinical chemistry, 4(4), 278-285 (1958-08-01)
J C Doxey et al.
British journal of pharmacology, 78(3), 489-505 (1983-03-01)
1 The selectivity and specificity of RX 781094 [2-(2-(1,4 benzodioxanyl))2-imidazoline HCl] for alpha-adrenoceptors have been examined in peripheral tissues. 2 In isolated tissue experiments RX 781094 was a competitive antagonist at prejunctional alpha 2-adrenoceptors situated on the sympathetic nerve terminals
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