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G5172

Sigma-Aldrich

GW4064

≥97% (HPLC)

Synonym(s):

3-(2,6-Dichlorophenyl)-4-(3’-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

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150 UNITS
¥3,624.54

¥3,624.54

Available to ship on2025年4月27日Details

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150 UNITS
¥3,624.54

About This Item

Empirical Formula (Hill Notation):
C28H22Cl3NO4
CAS Number:
278779-30-9
Molecular Weight:
542.84
MDL number:
MFCD09971006
UNSPSC Code:
12352200
PubChem Substance ID:
329799937
NACRES:
NA.32

¥3,624.54

Available to ship on2025年4月27日Details

Request a Bulk Order

Quality Level

100

Assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C)c1onc(c1COc2ccc(\C=C\c3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl

InChI

1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+

InChI key

BYTNEISLBIENSA-MDZDMXLPSA-N

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抗-HA-荧光素，高亲和力

antibody form

affinity purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

3F10, monoclonal

conjugate

alkaline phosphatase conjugate

conjugate

fluorescein conjugate

conjugate

alkaline phosphatase conjugate

conjugate

fluorescein conjugate

biological source

sheep

biological source

sheep

biological source

sheep

biological source

rat

form

solution

form

lyophilized

form

solution

form

lyophilized

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

General description

GW4064 is a synthetic isoxazole, which is used to decipher the cellular and physiological functions of farnesoid X receptor (FXR). It is an estrogen receptor-related receptors (ERRs) agonist.[1]

Application

GW4064 has been used:
  • to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosis[2]
  • to examine its capability to inhibit mucosal injury in ileum caused by lipopolysaccharide (LPS)[3]
  • to treat ileal explants[4]

Biochem/physiol Actions

GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Lot/Batch Number
    0000178121
    0000178122
    0000169326
    0000169326
    0000178122

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    Sarah Farr et al.
    American journal of physiology. Gastrointestinal and liver physiology, 318(4), G682-G693 (2020-02-01)
    Postprandial dyslipidemia is a common feature of insulin-resistant states and contributes to increased cardiovascular disease risk. Recently, bile acids have been recognized beyond their emulsification properties as important signaling molecules that promote energy expenditure, improve insulin sensitivity, and lower fasting
    Jing Yang et al.
    Frontiers in pharmacology, 8, 260-260 (2017-05-26)
    Triptolide (TP), a diterpenoid isolated from
    Esther M Verhaag et al.
    PloS one, 11(3), e0149782-e0149782 (2016-03-08)
    Cholestasis is characterized by accumulation of bile acids and inflammation, causing hepatocellular damage. Still, liver damage markers are highest in acute cholestasis and drop when this condition becomes chronic, indicating that hepatocytes adapt towards the hostile environment. This may be
    GW4064 attenuates lipopolysaccharide-induced hepatic inflammation and apoptosis through inhibition of the Toll-like receptor 4-mediated p38 mitogen-activated protein kinase signaling pathway in mice
    Liu HM, et al.
    International Journal of Molecular Medicine, 41(3), 1455-1462 (2018)
    Mingyi Liu et al.
    Frontiers in pharmacology, 11, 375-375 (2020-04-16)
    Berberine, a quinoline alkaloid, can be used in combination with statins to enhance hypolipidemic effects and reduce the dose and side effects of statins. The hypolipidemic effects of statins in the liver are mainly regulated by organic anion transporting polypeptides
    View All Related Papers

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