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D5412

Sigma-Aldrich

2′-Deoxyuridine

≥98.5%

Synonym(s):

1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside

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250 MG
CN¥691.12
100 MG
CN¥779.56
1 G
CN¥1,739.47
5 G
CN¥6,039.60

CN¥691.12

Available to ship onApril 23, 2025Details

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250 MG
CN¥691.12
100 MG
CN¥779.56
1 G
CN¥1,739.47
5 G
CN¥6,039.60

About This Item

Empirical Formula (Hill Notation):
C9H12N2O5
CAS Number:
951-78-0
Molecular Weight:
228.20
Beilstein:
24433
EC Number:
213-455-7
MDL number:
MFCD00006527
UNSPSC Code:
41106305
PubChem Substance ID:
24893831
NACRES:
NA.51

CN¥691.12

Available to ship onApril 23, 2025Details

New, lower price on this item!
Request a Bulk Order

biological source

synthetic (organic)

Quality Level

300

Assay

≥98.5%

form

powder

impurities

Thymidine, free

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

InChI key

MXHRCPNRJAMMIM-SHYZEUOFSA-N

Gene Information

mouse ... Slc29a1(63959)

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1 of 4

This Item
D5287D7400B5002
2′-Deoxyuridine ≥98.5%

D5412

2′-Deoxyuridine

2′-Deoxyinosine ≥98%

D5287

2′-Deoxyinosine

2′-Deoxyadenosine monohydrate ≥99%

D7400

2′-Deoxyadenosine monohydrate

5-Bromo-2′-deoxyuridine ≥99% (HPLC)

B5002

5-Bromo-2′-deoxyuridine

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥98.5%

assay

≥98%

assay

≥99%

assay

≥99% (HPLC)

form

powder

form

powder

form

powder

form

powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

solubility

water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

DMSO: 50 mg/mL, clear, colorless to very faintly yellow

impurities

Thymidine, free

impurities

inosine, essentially free

impurities

-

impurities

-

Application

2′-Deoxyuridine has been used as a:
  • precursor of [3H]thymidine triphosphate (TTP) in place of thymidine to avoid a potential thymidine block in relative proliferation assays[1]
  • nucleoside supplement for cell cycle synchronization and DNA replication inhibition[2]
  • mitotic inhibitor in culture media to minimize the proliferation of glial cells[3]

Biochem/physiol Actions

2′-Deoxyuridine (dU) is frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogs of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBF5010V
    BCCK9848
    BCCK2465
    BCCK2463
    BCCK2313

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    Kaori Nomura-Komoike et al.
    Scientific reports, 10(1), 1488-1488 (2020-02-01)
    Müller glia, the principal glial cell type in the retina, have the potential to reenter the cell cycle after retinal injury. In mammals, proliferation of Müller glia is followed by gliosis, but not regeneration of neurons. Retinal injury is also
    Quan-Liang Jian et al.
    PeerJ, 6, e5739-e5739 (2018-10-09)
    Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish
    Yang Yang et al.
    Cancer letters, 453, 170-183 (2019-04-08)
    Overexpression of NQO1 is associated with poor prognosis in human cancers including lung, stomach, colon, cervical, and pancreatic cancers. However, the molecular mechanisms underlying the protumorigenic capacities of NQO1 have not been fully elucidated. Here, we investigated this question and
    Hiroyuki Yamakoshi et al.
    Journal of the American Chemical Society, 134(51), 20681-20689 (2012-12-04)
    Alkyne has a unique Raman band that does not overlap with Raman scattering from any endogenous molecule in live cells. Here, we show that alkyne-tag Raman imaging (ATRI) is a promising approach for visualizing nonimmobilized small molecules in live cells.
    Hongxiu Ning et al.
    Cytotherapy, 15(1), 57-63 (2012-12-25)
    Thymidine analog 5-ethynyl-2-deoxyuridine (EdU) has recently been used for tracking mesenchymal stem cells (MSCs). In the present study, we tested whether EdU was cytotoxic and whether it interfered with differentiation, cytokine secretion and migration of MSCs. EdU labeling was performed
    View All Related Papers

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