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T9250

Sigma-Aldrich

Thymidine

≥99%

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Synonym(s):
1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil, 1-(2-Deoxy-β-D-ribofuranosyl)thymine, 2′-Deoxythymidine, Thymine deoxyriboside, dT
Empirical Formula (Hill Notation):
C10H14N2O5
CAS Number:
50-89-5
Molecular Weight:
242.23
Beilstein:
89285
EC Number:
200-070-4
MDL number:
MFCD00006537
UNSPSC Code:
41106305
PubChem Substance ID:
24900588
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

300

Assay

≥99%

form

powder

mp

186-188 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

InChI key

IQFYYKKMVGJFEH-XLPZGREQSA-N

Gene Information

human ... DTYMK(1841)

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General description

Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. It is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.

Application

Thymidine has been used:
  • as a supplement in HL5-modified medium for cell culture
  • to incubate cells in cell-cycle analysis
  • in cell synchronization

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Journal of medicinal chemistry, 51(21), 6689-6698 (2008-10-08)
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