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U3750

Sigma-Aldrich

Uridine

≥99%

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Synonym(s):
1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
58-96-8
Molecular Weight:
244.20
Beilstein:
754902
EC Number:
200-407-5
MDL number:
MFCD00006526
UNSPSC Code:
41106305
PubChem Substance ID:
24900640
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

Assay

≥99%

form

powder

mp

163-167 °C (lit.)

solubility

H2O: 50 mg/mL, clear, colorless

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-XVFCMESISA-N

Gene Information

mouse ... Uck1(22245)

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General description

Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid. Uridine is synthesized in living organisms by de novo and salvage pathways.

Application

Uridine has been used:
  • as a component of hippocampal neuron medium for culture of primary hippocampal neuron cells
  • in uridine rescue experiments in mouse embryonic fibroblasts and human breast cancer cells
  • in chase sequencing experiments

Biochem/physiol Actions

Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. Uridine has numerous biological functions like treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine are implicated in insulin resistance.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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PTEN regulates glutamine flux to pyrimidine synthesis and sensitivity to dihydroorotate dehydrogenase inhibition
Mathur D, et al.
Cancer Discovery, 7(4), 380390-380390 (2017)
Detection of phosphorylated Akt and MAPK in cell culture assays
Molgaard S, et al.
MethodsX, 3(2), 386398-386398 (2016)
Transient N-6-methyladenosine transcriptome sequencing reveals a regulatory role of m6A in splicing efficiency
Louloupi A, et al.
Cell Reports, 23(12), 34293437-34293437 (2018)
CAD mutations and uridine-responsive epileptic encephalopathy
Koch J, et al.
Brain, 140(2), 279286-279286 (2016)
Biochemistry of uridine in plasma
Yamamoto T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 412(19-20), 17121724-17121724 (2011)
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