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A4403

Sigma-Aldrich

L-Ascorbic acid

powder, suitable for cell culture, γ-irradiated

Synonym(s):

L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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20 EA
¥3,850.41

¥3,850.41

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¥3,850.41

About This Item

Empirical Formula (Hill Notation):
C6H8O6
CAS Number:
50-81-7
Molecular Weight:
176.12
Beilstein:
84272
EC Number:
200-066-2
MDL number:
MFCD00064328
UNSPSC Code:
12352207
PubChem Substance ID:
24890857
NACRES:
NA.75

¥3,850.41

Available to ship on2025年4月27日Details

Request a Bulk Order

biological source

synthetic (organic)

Quality Level

200

sterility

γ-irradiated

form

powder

mol wt

Mw 176.12 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

pH

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

solubility

H2O: 10 mg/mL

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This Item
853086853001852164
Boc-Trp-OH Novabiochem®

853038

Boc-Trp-OH

Boc-D-Trp-OH Novabiochem®

853086

Boc-D-Trp-OH

Boc-Ala-OH Novabiochem®

853001

Boc-Ala-OH

Fmoc-D-Trp(Boc)-OH Novabiochem®

852164

Fmoc-D-Trp(Boc)-OH

form

powder

form

powder

form

powder

form

powder

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥85.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

15-25°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

General description

L-ascorbic acid is an unsaturated γ-lactone ring containing an enediol configuration (–COH=COH) attached with a carbonyl group.[1]

Application

For use in cell culture applications as an antioxidant and to regenerate tocopherol.
L-ascorbic acid has been used:
  • in an osteogenic supplement for the growth of cells[2]
  • as a component in the differentiation media[3]
  • in WS-MSCs (Werner syndrome-mesenchymal stem cells) to study rescuing properties of ascorbic acid on aging defects[4]

Biochem/physiol Actions

L-ascorbic acid mainly exhibits antioxidant properties. It protects plants from oxidative stress and mammals from diseases associated with oxidative stress.[5] L-ascorbic acid mainly protects from hydroxyl radicals, superoxide and singlet oxygen. In addition, it also reduces the membrane-linked antioxidant α-tocopherol (oxidised form).[6] L-Ascorbic acid enhances endothelium-dependent vasodilation in various disorders, including diabetes, coronary artery disease, hypertension and chronic heart failure.[1]

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

recommended

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000411196
    0000411196
    0000346373
    0000316170
    0000316170

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    R Heller et al.
    The Journal of biological chemistry, 274(12), 8254-8260 (1999-03-13)
    Ascorbic acid has been shown to enhance impaired endothelium-dependent vasodilation in patients with atherosclerosis by a mechanism that is thought to involve protection of nitric oxide (NO) from inactivation by free oxygen radicals. The present study in human endothelial cells
    Plant L-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing.
    Davey MW
    Journal of the Science of Food and Agriculture, 80, 825-860 (2000)
    P L Conklin et al.
    Plant physiology, 115(3), 1277-1285 (1997-12-09)
    The biosynthesis of L-ascorbic acid (vitamin C) is not well understood in plants. The ozone-sensitive Arabidopsis thaliana mutant vitamin c-1 (vtc1; formerly known as soz1) is deficient in ascorbic acid, accumulating approximately 30% of wild-type levels. This deficiency could result
    Xi Wang et al.
    Archives of oral biology, 57(9), 1231-1240 (2012-03-30)
    This study focused on the characterization of stem cells from human exfoliated deciduous teeth (SHED) in comparison with dental pulp stem cells (DPSCs) to certify SHED as a key element in tissue engineering. In the present study, SHED and DPSCs
    Ying Li et al.
    Protein & cell, 7(7), 478-488 (2016-06-09)
    Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). This model recapitulates many phenotypic features of WS. Based
    View All Related Papers

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