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Merck
CN

D0627

N6,2′-O-二丁酰基腺苷 3′,5′-环单磷酸 钠盐

≥96% (HPLC), synthetic (organic), powder

别名:

二丁酰 cAMP 钠盐, 二丁酰环磷腺苷 钠盐, 布拉地新 钠盐

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关于此项目

线性分子式:
C18H23N5O8PNa
化学文摘社编号:
分子量:
491.37
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
241-059-4
MDL number:
Assay:
≥96% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: 100 mg/mL
Storage temp.:
−20°C
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产品名称

N6,2′-O-二丁酰基腺苷 3′,5′-环单磷酸 钠盐, ≥96% (HPLC), powder

biological source

synthetic (organic)

Quality Level

assay

≥96% (HPLC)

form

powder

impurities

≤0.5% Cyclic AMP, ≤3% monobutyryl derivatives

color

off-white

solubility

H2O: 100 mg/mL

storage temp.

−20°C

SMILES string

[Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC

InChI

1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1

InChI key

KRBZRVBLIUDQNG-JBVYASIDSA-M

Application

二丁酰基CAMP是一种可激活CAMP 依赖性蛋白激酶 (PKA)或CAMP/PKA信号传导途径的细胞可渗透型CAMP类似物。 二丁酰基CAMP可用作施万细胞等细胞的形态学分化诱导剂和细胞信号调节剂。 二丁酰基cAMP可用于多种分化研究,如神经元分化/神经分化。

Biochem/physiol Actions

细胞通透性 cAMP 类似物,可激活 cAMP 依赖性蛋白激酶 (PKA)。

Disclaimer

在 pH 8.5 下会失去 2′-O-丁酰基


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存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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实验方案

Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.


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Fertility and sterility, 99(1), 86-91 (2012-09-19)
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Annelieke S Wentzel et al.
Scientific reports, 10(1), 13470-13470 (2020-08-12)
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