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D0260

Sigma-Aldrich

N6,2′-O-二丁酰基腺苷 3′,5′-环单磷酸 钠盐

≥97% (HPLC), powder

别名:

二丁酰 cAMP 钠盐, 二丁酰环磷腺苷 钠盐, 布拉地新 钠盐

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CN¥782.78
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5 MG
CN¥782.78
25 MG
CN¥2,194.65
100 MG
CN¥5,868.36

About This Item

线性分子式:
C18H23N5O8PNa
CAS号:
16980-89-5
分子量:
491.37
EC 号:
241-059-4
MDL编号:
MFCD00005843
UNSPSC代码:
41106305
PubChem化学物质编号:
24893221
NACRES:
NA.77

CN¥782.78

国内现货，预计发货时间April 24, 2025详情

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质量水平

200

方案

≥97% (HPLC)

表单

powder

杂质

≤0.5% cyclic AMP and 2′-O-monobutyryl-cyclic AMP
≤3% N6-monobutyryl-cyclic AMP

颜色

white

溶解性

H2O: 100 mg/mL

储存温度

−20°C

SMILES字符串

[Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC

InChI

1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1

InChI key

KRBZRVBLIUDQNG-JBVYASIDSA-M

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此商品
D0627A6885M7510
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt ≥97% (HPLC), powder

D0260

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt ≥96% (HPLC), powder

D0627

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate ≥98.0% (HPLC), powder

A6885

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate

β,γ-Methyleneadenosine 5′-triphosphate disodium salt ≥95%, solid

M7510

β,γ-Methyleneadenosine 5′-triphosphate disodium salt

assay

≥97% (HPLC)

assay

≥96% (HPLC)

assay

≥98.0% (HPLC)

assay

≥95%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 10 mg/mL

solubility

H2O: 10 mg/mL

color

white

color

off-white

color

white

color

white

一般描述

二丁酰环磷酸腺苷(cAMP)具有类似内源性cAMP的活性。具有亲脂性，细胞渗透性更强，更能抵抗cAMP磷酸二酯酶的水解。二丁酰cAMP可抑制磷酸二酯酶，作为探针在信号转导通路中发挥重要作用。[1]

应用

N6,2′-O-二丁酰基腺苷3′,5′-环磷酸钠盐已用于：
  • 用作神经rest干细胞（NCSCs）分化的培养基补充剂[2]
  • 用作低温保存人iPSC（诱导多能干细胞）分化神经元解冻培养基的成分[3]
  • 无血清杜氏改良eagle′s培养基(DMEM)，诱导星形胶质细胞分化[4]

可作为分化培养基组分，用于底板祖细胞分化诱导为多巴胺神经元。[5]也作为DMEM:F12培养基补充剂，用于人多能干细胞来源的神经元细胞培养。[6]

生化/生理作用

细胞通透性 cAMP 类似物，可激活 cAMP 依赖性蛋白激酶 (PKA)。

特点和优势

该化合物是环核苷酸研究的特色产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

注意

在 pH 8.5 下会失去 2′-O-丁酰基

其他说明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000429579
    0000429579
    0000365752
    0000347088
    0000347087

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    Annagrazia Adornetto et al.
    FEBS open bio, 3, 459-466 (2013-11-20)
    In the central nervous system, alteration of glial cell differentiation can affect brain functions. Polychlorinated biphenyls (PCBs) are persistent environmental chemical contaminants that exert neurotoxic effects in glial and neuronal cells. We examined the effects of a commercial mixture of
    Differentiation of human induced pluripotent stem cell (hiPSC)-derived neurons in mouse hippocampal slice cultures
    Hiragi T, et al.
    Frontiers in Cellular Neuroscience, 11, 143-143 (2017)
    Han Zhao et al.
    The Science of the total environment, 908, 168307-168307 (2023-11-11)
    Atrazine (ATZ) is one of the most used herbicides in the US and a known endocrine disruptor. ATZ is frequently detected in drinking water, especially in Midwestern regions of the United States, exceeding the EPA regulation of maximum contamination level
    F Schwede et al.
    Pharmacology & therapeutics, 87(2-3), 199-226 (2000-09-29)
    Cyclic AMP (cAMP) and cyclic GMP (cGMP) are key second messengers involved in a multitude of cellular events. From the wealth of synthetic analogs of cAMP and cGMP, only a few have been explored with regard to their therapeutic potential.
    Daniel Sobrido-Cameán et al.
    Disease models & mechanisms, 12(2) (2019-02-03)
    Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin
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    Discover Bioactive Molecules for Nucleotides

    Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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