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Merck
CN

T1200000

Thiopental

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-Thiopental, 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid, Pentothal

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About This Item

Empirical Formula (Hill Notation):
C11H18N2O2S
CAS Number:
Molecular Weight:
242.34
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
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InChI

1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)

SMILES string

CCCC(C)C1(CC)C(=O)NC(=S)NC1=O

InChI key

IUJDSEJGGMCXSG-UHFFFAOYSA-N

API family

thiopental

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Thiopental EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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H Murdoch et al.
International journal of obstetric anesthesia, 22(1), 31-35 (2012-11-06)
A national survey of current practice and preferred drug choices for both induction and maintenance of general anaesthesia for caesarean section was undertaken. Following approval by the Obstetric Anaesthetists' Association, all UK consultant members were invited to respond to an
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Preliminary evidence suggests that the use of ketamine during electroconvulsive therapy (ECT) may be neuroprotective against cognitive impairment and have synergistic antidepressant effects. This study tested whether the addition of ketamine reduced cognitive impairment and enhanced efficacy over a course
Anna Rosati et al.
Neurology, 79(24), 2355-2358 (2012-12-01)
To evaluate the efficacy and safety of ketamine (KE) in the management of refractory convulsive status epilepticus (RSE) in children. In November 2009, we started using KE for treating all children consecutively referred for RSE. Clinical and treatment data were
Elisabeth Norman et al.
Pediatric research, 73(1), 87-94 (2012-11-07)
Sedative and analgesic medications are used in critically ill newborns, but little is known about their effects on electrocortical activity in preterm infants. We hypothesized that morphine might induce prolonged neurodepression, independent of blood pressure, as compared with rapid sequence
Chadi G Abdallah et al.
The journal of ECT, 28(3), 157-161 (2012-08-01)
Studies now provide strong evidence that the N-methyl-D-aspartate receptor antagonist ketamine possesses rapidly acting antidepressant properties. This study aimed to determine if a low dose of ketamine could be used to expedite and augment the antidepressant effects of electroconvulsive therapy

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