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10106399001

Roche

GTP

>90% (HPLC), crystals, pkg of 250 mg

Synonym(s):

Guanosine 5′-triphosphate sodium salt hydrate, 5′-GTP-Na2

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1 G
¥772.56
5 G
¥1,884.65
25 G
¥6,886.03

¥772.56

Available to ship on2025年4月14日Details

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1 G
¥772.56
5 G
¥1,884.65
25 G
¥6,886.03

About This Item

Empirical Formula (Hill Notation):
C10H16N5O14P3 · xNa+ · yH2O
CAS Number:
56001-37-7
Molecular Weight:
523.18 (anhydrous free acid basis)
Beilstein:
4113439
MDL number:
MFCD00149227
UNSPSC Code:
41106305
PubChem Substance ID:
329748894

¥772.56

Available to ship on2025年4月14日Details

description

Disodium salt

Quality Level

100

Assay

>90% (HPLC)

form

crystals

mol wt

Mr 523.2 (GTP)
Mr 567.1 (GTP-Na2)

packaging

pkg of 250 mg

manufacturer/tradename

Roche

storage condition

avoid repeated freeze/thaw cycles

SMILES string

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

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93285

2,4,6-三（2-吡啶基）- s -三嗪

3-（2-吡啶基）-5,6-二苯基-1,2,4-三嗪-4′,4′′-二磺酸 钠盐 BioXtra

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3-（2-吡啶基）-5,6-二苯基-1,2,4-三嗪-4′,4′′-二磺酸 钠盐

3-(2-吡啶基)-5,6-二(2-呋喃基)-1,2,4-三嗪-5′,5′′-二磺酸 二钠盐 Suitable for determination of Fe

P4272

3-(2-吡啶基)-5,6-二(2-呋喃基)-1,2,4-三嗪-5′,5′′-二磺酸 二钠盐

乙基己基三嗪酮

PHR2801

乙基己基三嗪酮

form

lumps

form

powder

form

powder or crystals

form

powder

quality

for spectrophotometric det. of Fe

quality

-

quality

-

quality

-

technique(s)

UV/Vis spectroscopy: suitable

technique(s)

-

technique(s)

-

technique(s)

-

loss

≤0.1 wt. % loss on drying

loss

-

loss

-

loss

-

mp

247-249 °C (lit.)

mp

≥300 °C

mp

-

mp

-

General description

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. It also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.[1] GTP is involved in the initiation of peptide synthesis during the binding of formylmethionyl-tRNA (F-met-tRNA) to the ribosome.[2][3] It is also involved in polypeptide chain elongation.[4] GTP is hydrolyzed by tubulin and its hydrolysis is accompanied by microtubule assembly.[5]
GTP is supplied as the disodium salt in crystal form.

Application

GTP, disodium salt, is required as a coenzyme for protein biosynthesis in a cell-free system. It has been used in FtsZ polymerization assay[6] and in the preparation of pipette solution for the electrophysiological recordings of the whole-cell membrane currents.[7]

Quality

Purity: 76% GTP (enzymatic), >90 area% (HPLC), 9% Na+, 8% H2O

Preparation Note

Activator: EDTA prevents the formation of enzyme aggregates. Phosphate stimulates the NADH-dependent reaction.
Storage conditions (working solution): Aqueous solutions (pH 7.0) are stable at 2 to 8 °C or frozen for approx. one week, for reasons of hydrolysis pH should not be < 3.

If neutralized with water preparation can be stored frozen at -15 to -25 °C in small portions, one sample should thawed only once and should be used within the next one or two days (stored at 2 to 8 °C). Preparation can also be dissolved in a buffer pH 7-8 without neutralization (buffer concentration should be high enough that pH is not changed by addition of those substances); solution can be stored frozen.

Investigations on the storage temperature 2 to 8 °C compared to -15 to -25 °C showed no difference.

Storage and Stability

Store at 2 to 8 °C. (Store dry!)

Analysis Note

Purity: 76% GTP (enzymatic), >90 area% (HPLC), 9% Na+, 8% H2O

Other Notes

For life science research only. Not for use in diagnostic procedures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    64374823
    64374822
    58128824
    40111825
    40111824

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    Ewa Król et al.
    Journal of visualized experiments : JoVE, (81)(81), e50844-e50844 (2013-12-05)
    During bacterial cell division, the essential protein FtsZ assembles in the middle of the cell to form the so-called Z-ring. FtsZ polymerizes into long filaments in the presence of GTP in vitro, and polymerization is regulated by several accessory proteins.
    Lehninger, A.L
    Biochemistry, 316-316 (1977)
    Alice Cezanne et al.
    eLife, 9 (2020-06-09)
    Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors, generating a positive feedback of GTPase activation
    The role of guanosine 5'-triphosphate in polypeptide chain elongation.
    Y Kaziro
    Biochimica et biophysica acta, 505(1), 95-127 (1978-09-21)
    Marzia Govoni
    Bio-protocol, 7(3), e2120-e2120 (2017-02-05)
    In eukaryotic cells transcriptional processes are carried out by three different RNA polymerases: RNA polymerase I which specifically transcribes ribosomal RNA (rRNA), RNA polymerase II which transcribes protein-coding genes to yield messenger RNAs (mRNAs) and small RNAs, while RNA polymerase
    View All Related Papers

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