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安全信息

Q3625

Sigma-Aldrich

奎尼丁

sodium channel blocker

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25 G
¥3,042.76

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About This Item

经验公式（希尔记法）:
C20H24N2O2
CAS号:
56-54-2
分子量:
324.42
Beilstein:
91866
EC 号:
200-279-0
MDL编号:
MFCD00135581
UNSPSC代码:
12352200
PubChem化学物质编号:
24899331
NACRES:
NA.77

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产品名称

奎尼丁, anhydrous

等级

anhydrous

质量水平

200

杂质

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

mp

168-172 °C (lit.)

创始人

Bayer

SMILES字符串

COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1

InChI key

LOUPRKONTZGTKE-LHHVKLHASA-N

基因信息

human ... ABCB1(5243) , CYP2D6(1565) , CYP3A4(1576) , KCNH1(3756) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
mouse ... Abcb1a(18671) , Abcb1b(18669)
rat ... Cyp2d1(266684) , Cyp2d2(25053) , Cyp2d3(24303) , Cyp2d4v1(171522)

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此商品
572330734624544841
钆掺杂的氧化铈(IV) nanopowder, contains 20 mol % gadolinium as dopant

572357

钆掺杂的氧化铈(IV)

钆掺杂的氧化铈(IV) nanopowder, contains 10 mol % gadolinium as dopant

572330

钆掺杂的氧化铈(IV)

氧化钐掺杂的氧化铈(IV) <0.5 μm particle size, powder, contains 20 mol % samarium as dopant

734624

氧化钐掺杂的氧化铈(IV)

氧化铈 IV nanopowder, <25 nm particle size (BET)

544841

氧化铈 IV

form

nanopowder

form

nanopowder

form

powder

form

nanopowder

contains

20 mol % gadolinium as dopant

contains

10 mol % gadolinium as dopant

contains

20 mol % samarium as dopant

contains

-

composition

Ce0.8Gd0.2O2

composition

Ce0.9Gd0.1O2

composition

Sm0.2Ce0.8O1.9

composition

-

reaction suitability

reagent type: catalyst
core: cerium

reaction suitability

reagent type: catalyst
core: cerium

reaction suitability

-

reaction suitability

reagent type: catalyst
core: cerium

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

-

应用

Quinidine has been used:
  • as an inhibitor of cytochrome P450 enzyme isoform CYP2D6[1]
  • as a potassium (K+) channel blocker in microglia[2]
  • to test its effect on electrophysiological behaviour of human induced pluripotent stem cells (hiPSC) cardiomyocytes[3]

生化/生理作用

IA 类抗心律失常药；钾通道阻断剂。
Quinidine, an isomer of quinine has potential side effects like proarrhythmia on usage. It prolongs cardiac potential and is sodium channel blocker.[4] It is a potential antagonist for α1-adrenoceptors and contributes to hypotension.[5] It inhibits cytochrome P450 2D6 and improves circulation and brain penetration of dementia drug, dextromethorphan.[6] Quinidine-dextromethorphan combination may be useful in treating pseudobulbar affect (PBA).[7]

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H317

危险分类

Acute Tox. 3 Oral - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    BCCM7633
    BCCK5236
    BCCH3397
    BCCF9916
    BCCC9051

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    访问文档库

    Danny Jans et al.
    Journal of pharmacological and toxicological methods, 87, 48-52 (2017-05-28)
    Drug-induced cardiotoxicity poses a negative impact on public health and drug development. Cardiac safety pharmacology issues urged for the preclinical assessment of drug-induced ventricular arrhythmia leading to the design of several in vitro electrophysiological screening assays. In general, patch clamp
    Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors
    Shibata K, et al.
    Circulation, 97(13), 1227-1230 (1998)
    Microglial ramification, surveillance, and interleukin-1beta release are regulated by the two-pore domain K+ channel THIK-1
    Madry C, et al.
    Neuron, 97(2), 299-312 (2018)
    Dextromethorphan/quinidine: a review of its use in adults with pseudobulbar affect
    Yang LPH and Deeks ED
    Drugs, 75(1), 83-90 (2015)
    Cardiac Sodium Channel Disorders An Issue of Cardiac Electrophysiology Clinics E-Book, 6(4) (2015)
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    商品

    Discover Bioactive Small Molecules for ADME/Tox

    Discover Bioactive Small Molecules for ADME/Tox

    实验方案

    LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

    LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

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