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质量水平
反应适用性
core: platinum
reagent type: catalyst
mp
280 °C (dec.) (lit.)
SMILES字符串
Cl[Pt]Cl.NC1CCCCC1N
InChI
1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2
InChI key
PNNCIXRVXCLADM-UHFFFAOYSA-L
警示用语：
Danger
危险分类
Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Sachiko Kaida et al.
Cancer research, 70(18), 7031-7041 (2010-08-06)
Nanoparticle therapeutics are promising platforms for cancer therapy. However, it remains a formidable challenge to assess their distribution and clinical efficacy for therapeutic applications. Here, by using multifunctional polymeric micellar nanocarriers incorporating clinically approved gadolinium (Gd)-based magnetic resonance imaging contrast
Kensuke Osada et al.
Journal of the American Chemical Society, 134(32), 13172-13175 (2012-07-28)
Spontaneous formation of polymeric metallosomes with uniform size (~100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of ω-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular
A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA.
S Choi et al.
Inorganic chemistry, 40(22), 5481-5482 (2001-10-16)
F Grolleau et al.
Journal of neurophysiology, 85(5), 2293-2297 (2001-05-16)
Oxaliplatin, a new widely used anticancer drug, displays frequent, sometimes severe, acute sensory neurotoxicity accompanied by neuromuscular signs that look like the symptoms observed in tetany and myotonia. The whole cell patch-clamp technique was employed to investigate the oxaliplatin effects
C B Oswald et al.
Research communications in chemical pathology and pharmacology, 64(1), 41-58 (1989-04-01)
The disposition of 3H-cis-1,2-diaminocyclohexanedichloroplatinum (II) and 3H-cis-1,2-diaminocyclohexanemalonatoplatinum (II) was investigated in P388 tumor-bearing BDF1 mice. Fifteen minutes after IP administration of the drugs, the serum contained 12% of the 3H-chloride derivative and 20% of the malonate derivative. Both drugs distributed
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