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Merck
CN

244929

Dichloro(ethylenediamine)platinum(II)

99%, solid

Synonym(s):

Dichloro(1,2-diaminoethane)platinum, Dichloro(1,2-ethanediamine)platinum, Platinum ethylenediamine dichloride

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About This Item

Linear Formula:
(H2NCH2CH2NH2)PtCl2
CAS Number:
14096-51-6
Molecular Weight:
326.08
NACRES:
NA.22
PubChem Substance ID:
24854717
UNSPSC Code:
12161600
EC Number:
237-943-4
MDL number:
MFCD00000011

Key Documents

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Product Name

Dichloro(ethylenediamine)platinum(II), 99%

InChI key

LMABILRJNNFCPG-UHFFFAOYSA-L

InChI

1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2

SMILES string

Cl[Pt]Cl.NCCN

assay

99%

form

solid

reaction suitability

core: platinum
reagent type: catalyst

Quality Level

100

Related Categories

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000412099
0000412099
0000238172
0000227773
0000224991

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B E Bowler et al.
Biochemistry, 25(10), 3031-3038 (1986-05-20)
We report the DNA binding site preferences of the novel molecule AO-Pt, in which the anticancer drug dichloro(ethylenediamine)platinum(II) is linked by a hexamethylene chain to acridine orange. The sequence specificity of platinum binding was mapped by exonuclease III digestion of
W L Armarego et al.
European journal of biochemistry, 164(2), 403-409 (1987-04-15)
Potassium tetrachloroplatinate (K2PtCl4) inactivates dihydropteridine reductase from human brain in a time-dependent and irreversible manner. The inactivation has been followed by measuring enzyme activity and fluorescence changes. The enzyme is completely protected from inactivation by NADH, the pterin cofactor [quinonoid
T J Kelley et al.
Cancer biochemistry biophysics, 13(3), 135-146 (1993-06-01)
Cisplatin (cis-diamminedichloroplatinum(II); cis-DDP) is used as an effective drug for treatment of a variety of cancers, such as carcinomas of bladder, ovarian, and testicular origin. Immunopurified DNA polymerase-alpha from rat prostate tumor PA-3 cells was inhibited (50%) in the presence
E Kimura et al.
Cancer chemotherapy and pharmacology, 32(6), 419-424 (1993-01-01)
Expression of the heat-shock protein HSP-60 is associated with poor survival in patients with ovarian carcinoma. We examined both the nature of the interaction between hyperthermia and cisplatin (DDP) using the human ovarian carcinoma cell line 2008 and the effect
J D Bell et al.
Journal of inorganic biochemistry, 31(4), 241-246 (1987-12-01)
Reactions of cis-PtCl2(NH3)2 (1), Pt(1,2-diaminoethane)Cl2 (2), PtCl4(2-) (3), and AuCl4- (4) with intact cell culture media have been studied by spin-echo 500 MHz proton NMR spectroscopy. This has allowed us to observe reactions of components of the media at submillimolar
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