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15023AST

Supelco

Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns

L × I.D. 15 cm × 4.6 mm, HPLC Column

Synonym(s):

CHIROBIOTIC V2 Chiral Chromatography Column

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250 MG
CN¥746.15
1 G
CN¥1,887.16
10 G
CN¥9,785.13

CN¥746.15

Available to ship onApril 25, 2025Details

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250 MG
CN¥746.15
1 G
CN¥1,887.16
10 G
CN¥9,785.13

About This Item

UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

CN¥746.15

Available to ship onApril 25, 2025Details

Product Name

Astec® CHIROBIOTIC® V2 Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

material

stainless steel column

Quality Level

100

Agency

suitable for USP L88

description

HPLC column

product line

Astec®

packaging

pkg of 1 ea

manufacturer/tradename

Astec®

parameter

0-45 °C temperature
241 bar pressure (3500 psi)

technique(s)

HPLC: suitable
LC/MS: suitable

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Show Differences

1 of 4

This Item
D3159D1626D3664
Deoxyribonucleic acid sodium salt from herring testes Type XIV

D6898

Deoxyribonucleic acid sodium salt from herring testes

Deoxyribonucleic acid from herring sperm not suitable for substrate for typical DNase assays (“crude oligonucleotides", <50 bp), degraded

D3159

Deoxyribonucleic acid from herring sperm

Deoxyribonucleic acid sodium salt from salmon testes

D1626

Deoxyribonucleic acid sodium salt from salmon testes

Sigma-Aldrich

D3664

Deoxyribonucleic acid sodium salt from calf thymus

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

powder

form

solid

form

powder or crystals

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

type

Type XIV

type

-

type

-

type

-

General description

Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

  • Bonded phase: Vancomycin
  • Operating pH range: 3.5 - 7.0
  • Particle diameter: 5, 10 or 16 μm
  • Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)

CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature

Application


  • Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study.: This research showcases the Astec® CHIROBIOTIC® V2 Chiral HPLC Column′s capacity for precise enantioselective analysis in pharmacokinetic studies, specifically for psychoactive substances. It highlights the column′s effectiveness in separating and quantifying chiral drugs and their metabolites in plasma, providing valuable insights for drug development and therapeutic monitoring (Zhang et al., 2016).

  • New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.: This study illustrates the use of the Astec® CHIROBIOTIC® V2 Chiral HPLC Column for the chiral separation of warfarin enantiomers. The methodology developed provides a robust tool for the analysis of anticoagulant drugs, aiding in the assessment of their pharmacokinetics and optimizing dosage for therapeutic efficacy (Malakova et al., 2009).

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    290759-06
    290759-05
    290759-04
    290759-03
    290759-02

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Chromatography Liquid Chiral Separations
    Xiao, T.L., et al.
    Encyclopedia of Separation Science, 1-15 (2000)
    Doris Frühauf et al.
    Journal of chromatography. A, 1269, 242-254 (2012-10-30)
    A sub-minute enantioselective normal phase high performance liquid chromatographic (HPLC) method for the analysis of a chiral precursor molecule employed frequently in folic acid syntheses was developed, optimized and successfully validated according to ICH-guidelines. It could be shown that ultra-high
    New chemo-enzymatic approaches for the synthesis of (R)- and (S)-bufuralol
    Nagy, Botond, et al.
    Tetrahedron Asymmetry, 25 (18-19), 1316-1322 (2014)
    Validation of a chiral liquid chromatography?tandem mass spectrometry method for the determination of pantoprazole in dog plasma
    Chen, Meixia, et al.
    Journal of Chromatography. B, Biomedical Sciences and Applications, 906, 85-90 (2012)
    Enantioselective and sensitive determination of carvedilol in human plasma using chiral stationary-phase column and reverse-phase liquid chromatography with tandem mass spectrometry
    Jiang, Juanjuan, et al.
    Journal of Chromatography. B, Biomedical Sciences and Applications, 960, 92-97 (2014)
    View All Related Papers

    Protocols

    Accurate Biological Testing for Amphetamine and Methamphetamine Abuse Using Chiral HPLC and MS Detection

    Optimized sample prep and chiral chromatography methods for the LC/MS analysis of these drug enantiomers in urine

    Biological Testing for Amphetamine and Methamphetamine Abuse

    In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine.

    Chromatograms

    application for HPLC

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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