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SML2233

Sigma-Aldrich

XMU-MP-1 hydrochloride

≥98% (HPLC)

Synonym(s):

4-((5,10-Dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide hydrochloride, 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide hydrochoride

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1 ML
¥1,076.08
5 ML
¥4,941.99

¥1,076.08

List Price¥1,506.50Save 29%

Estimated to ship on2025年4月27日Details

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1 ML
¥1,076.08
5 ML
¥4,941.99

About This Item

Empirical Formula (Hill Notation):
C17H16N6O3S2 · xHCl
CAS Number:
2061980-01-4
Molecular Weight:
416.48 (free base basis)
MDL number:
MFCD30377214
UNSPSC Code:
12352200
NACRES:
NA.77

¥1,076.08

List Price¥1,506.50Save 29%

Estimated to ship on2025年4月27日Details

Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

CN(C1=CN=C(NC2=CC=C(S(N)(=O)=O)C=C2)N=C1N(C)C3=C4SC=C3)C4=O

InChI

1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21)

InChI key

YRDHKIFCGOZTGD-UHFFFAOYSA-N

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539132

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form

aqueous solution (dark coloration may develop upon storage, which does not affect the activity)

form

DMSO solution

form

lyophilized powder

form

lyophilized

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

wet ice

shipped in

-

shipped in

wet ice

Biochem/physiol Actions

Potent, reversible, ATP-competitive pan-MST kinase inhibitor with in vivo liver and intestinal tissue repair/regeneration efficacy.
XMU-MP-1 inhibits MST kinase activity (IC50 = 9.8 nM/MST1, 18.2 nM/MST2, 44.8 nM/MST3, 27.3 nM/MST4) in a reversible and ATP-competitive manner (MST1 IC50/[ATP] = 164 nM/10 μM and 4036 nM/300 μM; MST2 IC50/[ATP] = 34 nM/10 μM and 1498 nM/300 μM), exhibiting significant affinity and/or inhibitory potency toward only 17 other kinases among a panel of 468 (401 unique kinases). XMU-MP-1 selectively inhibits H2O2-stimulated MST autophosphorylation and phosphorylation of endogenous MST1/2 substrates (MOB1, LATS, YAP), but not JNK, in human and murine cells (Effective conc. 1 μM), effectively upregulating YAP nuclear localization and protecting HepG2 cells (3 μM) against MST2 overexpression-induced cell death. XMU-MP-1 exhibits in vivo efficacy toward liver and intestinal repair and regeneration in various murine models (1-3 mg/kg/day i.p.) and oral availability in rats (t1/2 = 5.18 h, Tmax = 3 h, AUC = 993 ng•h/mL, F = 39.48%; 10 mg/mL p.o.).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000134148
    0000134150
    0000106705
    0000106706
    0000083363

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