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Key Documents

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SML1332

Sigma-Aldrich

NG25 trihydrochloride

≥98% (HPLC)

Synonym(s):

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide trihydrochloride, NG 25 trihydrochloride

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100 TESTS
CN¥13,220.39

CN¥13,220.39

Estimated to ship onAugust 05, 2025Details

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100 TESTS
CN¥13,220.39

About This Item

Empirical Formula (Hill Notation):
C29H30F3N5O2 · 3HCl
CAS Number:
1315355-93-1
Molecular Weight:
646.96
MDL number:
MFCD19443255
UNSPSC Code:
12352200
PubChem Substance ID:
329825790
NACRES:
NA.77

CN¥13,220.39

Estimated to ship onAugust 05, 2025Details

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC=C(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1OC4=C(C=CN5)C5=NC=C4

InChI

1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)

InChI key

SMPGEBOIKULBCT-UHFFFAOYSA-N

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manufacturer/tradename

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suitability

enterovirulent E. coli (EEC) (shiga toxigenic)

suitability

enterovirulent E. coli (EEC) (shiga toxigenic)

suitability

Escherichia coli (O157:H7)

suitability

enterovirulent E. coli (EEC) (shiga toxigenic)

compatibility

for use with GDS Rotor-Gene

compatibility

for use with GDS Rotor-Gene

compatibility

for use with GDS Rotor-Gene

compatibility

for use with GDS Rotor-Gene

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

Application

NG25 trihydrochloride has been used as a transforming growth factor β (TGFβ)-activated kinase 1 inhibitor (TAK1)[1] in human umbilical vein endothelial cells (HUVECs)[2] and pulmonary artery smooth muscle cells.[3]

Biochem/physiol Actions

NG25 is multiple kinase inhibitor; potent dia; omjobotpr pf TAK1 and MAP4K2 kinases.
NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

Other Notes

Light sensitive

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Lot/Batch Number
    0000203456
    0000203457
    0000203457
    0000203456
    0000131925

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    American journal of physiology. Lung cellular and molecular physiology, 316(1), L20-L34 (2018-09-28)
    TGFβ activation during newborn lung injury decreases the expression of pulmonary artery smooth muscle cell (PASMC)-soluble guanylate cyclase (sGC), a critical mediator of nitric oxide signaling. Using a rat PASMC line (CS54 cells), we determined how TGFβ downregulates sGC expression.
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