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SHCLNG

Sigma-Aldrich

MISSION® shRNA

Bacterial Stock

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About This Item

UNSPSC Code:
41106609

Quality Level

200

shipped in

dry ice

storage temp.

−70°C

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General description

Our comprehensive shRNA product offering consists of over 150,000 pre-cloned shRNA constructs targeting more than 15,000 human and 15,000 mouse genes. The library is available in: gene family sets: gene collections related to specific functional classes such as kinases and ion channels; gene taget sets, sets of shRNA clones that target your favorite gene; and individual shRNA clones. Our shRNA and lentiviral manufacturing platforms utilize dedicated laboratories featuring state-of-the-art robotics, liquid handling and laboratory information management systems (LIMS) to provide superior quality and service for your RNAi research needs.
MISSION® TRC shRNA bacterial glycerol stocks offer a renewable resource for shRNA plasmids. These plasmids can then be transfected directly, or packaged into lentiviral particles.

Application

MISSION® shRNA has been used in the generation of damage-regulated autophagy modulator (DRAM) and p73 knockdown cell lines. It has also been used in lentivirus generation and gene knockdown and to investigate the contribution of PAX8 (paired box 8) in ovarian cancer progression.

Other Notes

To see protocols and application data please visit sigma.com/shrna.

Legal Information

Use of this product is subject to one or more license agreements.
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells
Humbert M, et al.
Leukemia Research, 36(12), 1552-1556 (2012)
A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells
Di P, et al.
BMC Cancer, 14(1), 292-292 (2014)
Nicola Currey et al.
Cellular and molecular gastroenterology and hepatology, 7(4), 819-839 (2019-03-05)
The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous lesions or polyps is not known. Here
Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma
Huang Y, et al.
Blood, 125(9), 1435-1443 (2015)
Sun-Ji Park et al.
Free radical biology & medicine, 108, 44-55 (2017-03-23)
Luteal regression is a natural and necessary event to regulate the reproductive process in all mammals. Prostaglandin F2α (PGF2α) is the main factor that causes functional and structural regression of the corpus luteum (CL). It is well known that PGF2α-mediated
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Articles

MISSION® Lentiviral shRNA

MISSION shRNA reduce the expression of specific target genes by targeting the specific mRNA therefore reducing the corresponding protein expression.

Efficient Gene Silencing with MISSION® TRC shRNA

RNAi Consortium (TRC): Collaborative effort among academic labs and biotech/pharma institutes advancing RNA interference research.

Related Content

shRNAs for Individual Genes

Find shRNAs for Individual Genes. Over 150,000 pre-cloned shRNA constructs targeting more than 15,000 human and 15,000 mouse genes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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