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SML0021

Sigma-Aldrich

PDI inhibitor 16F16

≥98% (HPLC)

Synonym(s):

2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

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25 REACTIONS
CN¥2,002.48
100 REACTIONS
CN¥7,593.37
500 REACTIONS
CN¥37,946.95

CN¥2,002.48

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25 REACTIONS
CN¥2,002.48
100 REACTIONS
CN¥7,593.37
500 REACTIONS
CN¥37,946.95

About This Item

Empirical Formula (Hill Notation):
C16H17ClN2O3
CAS Number:
922507-80-0
Molecular Weight:
320.77
MDL number:
MFCD20134198
UNSPSC Code:
12352200
PubChem Substance ID:
329825093
NACRES:
NA.77

CN¥2,002.48

Please contact Customer Service for Availability
New, lower price on this item!
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: 12 mg/mL, clear

storage temp.

2-8°C

SMILES string

COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl

InChI

1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3

InChI key

BCSIRYFYAKLJDK-UHFFFAOYSA-N

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11483188001

RT-PCR第一条链cDNA合成试剂盒（AMV）

usage

sufficient for 100 reactions

usage

sufficient for 100 reactions

usage

-

usage

sufficient for 30 reactions (including 5 control reactions)

feature

dNTPs included

feature

dNTPs included, hotstart: no

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dNTPs included, hotstart: no

color

colorless

color

colorless

color

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color

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input

purified RNA

input

purified DNA

input

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input

purified RNA

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

shipped in

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Application

PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.[1]
PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.

Biochem/physiol Actions

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

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