All Photos(1)
Synonym(s):
2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
Empirical Formula (Hill Notation):
C16H17ClN2O3
CAS Number:
Molecular Weight:
320.77
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: 12 mg/mL, clear
storage temp.
2-8°C
SMILES string
COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl
InChI
1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
InChI key
BCSIRYFYAKLJDK-UHFFFAOYSA-N
Application
PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.
PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.
Biochem/physiol Actions
16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Ying Yuan et al.
Materials today. Bio, 21, 100697-100697 (2023-06-22)
Anastomotic thrombosis prevalently causes anastomosis failure, accompanied with ischemia and necrosis, the early diagnosis of which is restricted by inherent shortcomings of traditional imaging techniques in clinic and lack of appropriate prodromal biomarkers for thrombosis initiation. Herein, a fresh thrombus-specific
Nayeli Aguilar-Hernández et al.
Viruses, 13(1) (2021-01-06)
Although human astroviruses (HAstVs) are important agents of gastroenteritis in young children, the studies aimed at characterizing their biology have been limited, in particular regarding their cell entry process. It has been shown that HAstV serotype 8 enters human cells
A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion
Torpe N, et al.
Cell Reports, 26(12), 3183-3190 (2019)
Nanna Torpe et al.
Cell reports, 26(12), 3183-3190 (2019-03-21)
Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized. Here, we report that protein disulfide isomerase-1 (PDI-1), a protein-folding
Suma Yarapureddy et al.
Neoplasia (New York, N.Y.), 21(6), 516-532 (2019-04-28)
Patients with metastatic or relapsed/refractory osteosarcoma (OS) have a 5-year survival rate of <30%. This has remained unchanged over several decades. One of the factors contributing to lack of improvement in survival is the development of chemoresistance. Hence, elucidating and
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