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Safety Information

I1395

Sigma-Aldrich

IL-6 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-6 human, hIL-6, IL-6

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10 μG
CN¥3,074.42
50 μG
CN¥8,647.73

CN¥3,074.42

Available to ship onApril 23, 2025Details

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10 μG
CN¥3,074.42
50 μG
CN¥8,647.73

About This Item

MDL number:
MFCD00131403
UNSPSC Code:
12352202
NACRES:
NA.77

CN¥3,074.42

Available to ship onApril 23, 2025Details

Request a Bulk Order

Product Name

Interleukin-6 human, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

300

recombinant

expressed in E. coli

Assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

0.2-2.0 ng/mL ED50/EC50

quality

endotoxin tested

mol wt

26 kDa

packaging

pkg of 10 and 50 μg

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1 of 4

This Item
11138600001H7416SCU0001
Interleukin-6 human IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

I1395

Interleukin-6 human

Interleukin-6, human (hIL-6) recombinant (E. coli)

11138600001

Interleukin-6, human (hIL-6)

Interleukin-6 human IL-6, recombinant, expressed in HEK 293 cells, suitable for cell culture

H7416

Interleukin-6 human

Interleukin-6 human recombinant, expressed in HEK 293 cells, suitable for cell culture

SCU0001

Interleukin-6 human

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

assay

≥97% (SDS-PAGE)

assay

>98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

Quality Level

300

Quality Level

100

Quality Level

100

Quality Level

200

form

lyophilized powder

form

solution

form

lyophilized powder

form

lyophilized powder

Biochem/physiol Actions

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffer saline (PBS), pH 7.4, containing 500 μg bovine serum albumin.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000287869
    0000287869
    0000239111
    0000239110
    0000239111

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    Cancer letters, 433, 18-32 (2018-06-23)
    Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are
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    Nature communications, 11(1), 5455-5455 (2020-10-30)
    The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ
    Hemn Mohammadpour et al.
    Cell reports, 37(4), 109883-109883 (2021-10-28)
    Myeloid-derived suppressor cells (MDSCs) impede antitumor immunity; however, the precise mechanisms that regulate their suppressive function remain unresolved. Identifying these mechanisms could lead to therapeutic interventions to boost cancer immunotherapy efficacy. Here, we reveal that β2 adrenergic receptor (β2-AR) expression
    Bin Zhang et al.
    Stem cells and development, 23(11), 1233-1244 (2013-12-26)
    Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle, is immunologically active. MSC exosomes induced polymyxin-resistant, MYD88-dependent secreted embryonic alkaline phosphatase (SEAP) expression in a THP1-Xblue
    Adriana Catalli et al.
    PloS one, 9(5), e96891-e96891 (2014-05-14)
    Despite the fact that glucocorticoids and long acting beta agonists are effective treatments for asthma, their effects on human mast cells (MC) appear to be modest. Although MC are one of the major effector cells in the underlying inflammatory reactions
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    Articles

    Interleukin Family (IL)

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