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Safety Information

I2644

Sigma-Aldrich

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

IL-2, Interleukin-2, Interleukin-2 human, T-cell growth factor, hIL-2

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100 ASSAYS
CN¥4,383.64

CN¥4,383.64

Estimated to ship onApril 28, 2025Details

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100 ASSAYS
CN¥4,383.64

About This Item

MDL number:
MFCD00165721
UNSPSC Code:
12352202
NACRES:
NA.77

CN¥4,383.64

Estimated to ship onApril 28, 2025Details

Request a Bulk Order

Product Name

Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in E. coli

form

lyophilized powder

potency

≤700 EC50

quality

endotoxin tested

mol wt

15.5 kDa

packaging

pkg of 5X10 μg
pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

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Show Differences

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This Item
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Anti-FMC-7 B-Cell Lymphocyte Marker Antibody, clone FMC-7, FITC conjugated clone FMC-7, Chemicon®, from mouse

MAB1217F

Anti-FMC-7 B-Cell Lymphocyte Marker Antibody, clone FMC-7, FITC conjugated

Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 clone 2A10, Milli-Mark®, from mouse

FCMAB135F

Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10

Milli-Mark® Anti-CD27-FITC Antibody, clone M-T271 clone M-T271, Milli-Mark®, from mouse

FCMAB191F

Milli-Mark® Anti-CD27-FITC Antibody, clone M-T271

Milli-Mark® Anti-CD23-FITC Antibody, clone MHM6 clone MHM6, Milli-Mark®, from mouse

FCMAB187F

Milli-Mark® Anti-CD23-FITC Antibody, clone MHM6

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

purified antibody

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

clone

FMC-7, monoclonal

clone

2A10, monoclonal

clone

M-T271, monoclonal

clone

MHM6, monoclonal

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27.[1] IL-2 is originally called as T cell growth factor.[2]

Application

Interleukin-2 human has been used:
  • in the stimulation of natural killer cells[3]
  • to study its ability to stimulate lymphocyte growth and prevent apoptosis[4]
  • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus[5]

Biochem/physiol Actions

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages.[1] It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease.[6] IL-2 is associated with apoptosis and thus, possesses antitumor response.[7] It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.[1]

Physical form

Lyophilized, 0.2 μm filtered, no additives.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000293944
    0000293944
    SLCF9838
    SLBR5404V
    SLBR0355V

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    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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    Find documentation for the products that you have recently purchased in the Document Library.

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    1. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    2. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    3. Where can I find information on the specific activity of Product I2644, Interleukin-2 human - recombinant?

      The EC50 has been determined by dose-dependent stimulation of the proliferation of murine CTLL-2 cells.  You can find the lot specific value for the EC50 of this product on the Certificate of Analysis.  Certificates of Analysis can be viewed on our website by entering the lot number on the product detail page (for I2644).

    4. Is Product I2644, Interleukin-2 human - recombinant, endotoxin tested?

      Yes, the endotoxin levels are reported on the Certificate of Analysis.  Certificates of Analysis can be viewed on our website by entering the lot number on the product page (for I2644).

    5. How can I convert the EC50 of interleukin from ng/mL to units/mL when using Product I2644, Interleukin-2 human - recombinant?

      The specific activity in Units/mg = 1 × 106 / ED50 (in ng/ml).

    6. How should I dissolve Product I2644, Interleukin-2 human - recombinant?

      Reconstitute the contents of the vial using 100 mM acetic acid to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers.

    7. How should solutions of Product I2644, Interleukin-2 human - recombinant, be stored?

      Interleukin solutions can be stored at 2-8°C for up to 1 week. For extended storage, freeze at -20°C in working aliquots to avoid freezing and thawing.

    8. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    9. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    10. My question is not addressed here, how can I contact Technical Service for assistance?

      Ask a Scientist here.

    Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype
    Pridgeon C, et al.
    Rheumatology (Basel), 42(7), 870-878 (2003)
    Stefania Braidotti et al.
    Frontiers in bioscience (Landmark edition), 27(2), 39-39 (2022-03-01)
    The T-cell engager antibody blinatumomab (BlincytoT⁢M) represents a promising rescue therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab creates a tight synapsis between CD3+ T-lymphocytes and leukemic CD19+ B-cells
    Interleukin 2, 37-37 (2012)
    Association of- 330 interleukin-2 gene polymorphism with oral cancer
    Singh PK, et al.
    The Indian Journal of Medical Research, 146(6), 730-730 (2017)
    Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians
    Rahman HAA, et al.
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 35(2), 99-99 (2018)
    View All Related Papers

    Articles

    Interleukin Family (IL)

    Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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