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G5668

Sigma-Aldrich

GW1929 hydrate

>98% (HPLC), solid

Synonym(s):

N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate

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5 G
CN¥387.59
25 G
CN¥1,337.22

CN¥387.59

Available to ship onApril 11, 2025Details

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5 G
CN¥387.59
25 G
CN¥1,337.22

About This Item

Empirical Formula (Hill Notation):
C30H29N3O4 · xH2O
CAS Number:
1049740-86-4
Molecular Weight:
495.57 (anhydrous basis)
MDL number:
MFCD11045925
UNSPSC Code:
12352200
PubChem Substance ID:
24278789
NACRES:
NA.77

CN¥387.59

Available to ship onApril 11, 2025Details

Request a Bulk Order

Assay

>98% (HPLC)

form

solid

solubility

DMSO: 20 mg/mL

originator

GlaxoSmithKline

SMILES string

[H]O[H].CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(O)=O)cc1)c4ccccn4

InChI

1S/C30H29N3O4.H2O/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-21H2,1H3,(H,35,36);1H2/t27-;/m0./s1

InChI key

XSITZVFUXCLFMK-YCBFMBTMSA-N

Gene Information

human ... PPARG(5468)

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This Item
810800P800811C800811O
18:1 DGPP dioleoylglycerol pyrophosphate (ammonium salt), powder

810811P

18:1 DGPP

08:0 DGPP Avanti Research™ - A Croda Brand 810800P, powder

810800P

08:0 DGPP

18:1 DG 1-2-dioleoyl-sn-glycerol, chloroform

800811C

18:1 DG

18:1 DG Avanti Research™ - A Croda Brand

800811O

18:1 DG

packaging

pkg of 1 × 5 mg (810811P-5mg)

packaging

pkg of 1 × 10 mg (810800P-10mg)

packaging

pkg of 1 × 5 mL (800811C-10mg), pkg of 1 × 5 mL (800811C-25mg), pkg of 1 × 8 mL (800811C-200mg)

packaging

pkg of 1 × 10 mg (with screw cap (800811O-10mg)), pkg of 2 × 100 mg (with screw cap (800811O-200mg)), pkg of 5 × 100 mg (with screw cap 800811O-500mg), pkg of 1 × 25 mg (with screw cap (800811O-25mg))

form

powder

form

powder

form

liquid

form

liquid

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

manufacturer/tradename

Avanti Polar Lipids 810811P

manufacturer/tradename

Avanti Polar Lipids 810800P

manufacturer/tradename

Avanti Polar Lipids 800811C

manufacturer/tradename

Avanti Polar Lipids

Application

GW1929 has been used as a peroxisome proliferator-activated receptor γ (PPARγ) ligand:
  • to study its effects on plant homeodomain finger protein 16 (Phf16) and patatin-like phospholipase domain containing 3 (Pnpla3) expression involved in adipogenesis[1]
  • to study its effects on complement component 3 (C3) gene expression in human hepatoma cells[2]
  • to activate PPARγ in human breast cancer cells[3]

Biochem/physiol Actions

GW1929 is a high affinity agonist of PPAR-γ.
GW1929 is a non-thiazolidinedione and is involved in cell growth inhibition and regulating gene expression.[4] It exhibits neuroprotective effects against global cerebral ischemic-reperfusion injury by DNA fragmentation and minimizing the inflammation.[5] GW1929 participates in the inhibition of α7 N-acetylcholine receptor expression and promoter activity. It also influences the early growth response-1 (Egr-1) protein expression.[4]

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes only, pursuant to an agreement with Glaxo­Smith­Kline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000380855
    0000242261
    0000380855
    0000242261
    129K4708V

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    Swei Sunny Hahn et al.
    Cellular signalling, 26(4), 730-739 (2014-01-15)
    Studies demonstrated that peroxisome proliferator-activated receptor gamma (PPARγ) ligands reduce nicotine-induced non small cell lung carcinoma (NSCLC) cell growth through inhibition of nicotinic acetylcholine receptor (nAChR) mediated signaling pathways. However, the mechanisms by which PPARγ ligands inhibited nAChR expression remain
    Seo-Hyuk Chang et al.
    Journal of cellular biochemistry, 120(3), 3599-3610 (2018-10-03)
    Adipocyte differentiation is controlled by multiple signaling pathways. To identify new adipogenic factors, C3H10T1/2 adipocytes were treated with previously known antiadipogenic phytochemicals (resveratrol, butein, sulfuretin, and fisetin) for 24 hours. Commonly regulated genes were then identified by transcriptional profiling analysis. Three
    Ravinder K Kaundal et al.
    Behavioural brain research, 216(2), 606-612 (2010-09-14)
    Transient global cerebral ischemia results in acute neurodegeneration in selective brain areas. Global cerebral ischemic-reperfusion (IR) injury induced selective hippocampal damage results into various neurobehavioral deficits including spatial memory and learning deficiencies. In this study, we have investigated the protective
    Miaozhen Pan et al.
    Experimental eye research, 202, 108332-108332 (2020-11-06)
    Form deprivation myopia (FDM) is characterized by loss of choroidal thickness (ChT), reduced choroidal blood perfusion (ChBP), and consequently scleral hypoxia. In some tissues, changes in levels of peroxisome proliferator-activated receptor γ (PPARγ) expression modulate hypoxia-induced pathological responses. We determined
    Vladimir S Shavva et al.
    European journal of cell biology, 97(3), 204-215 (2018-03-20)
    C3 is an acute phase protein, and thus its plasma concentration increases quickly and drastically during the onset of inflammation. Insulin plays a complex role in inflammation. Elevated level of plasma C3 was shown to correlate with heightened fasting insulin
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