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Merck
CN

M157

MEN-10,376

≥95% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C57H68N12O10
CAS Number:
135306-85-3
Molecular Weight:
1081.22
NACRES:
NA.32
PubChem Substance ID:
24896670
UNSPSC Code:
51111800
MDL number:
MFCD00144736

Key Documents

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Product Name

MEN-10,376, ≥95% (HPLC), solid

InChI

1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)

SMILES string

CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O

InChI key

QQHOFZNACVKNHK-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

color

white

storage temp.

−20°C

Quality Level

200

Gene Information

human ... TACR2(6865)

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Biochem/physiol Actions

Potent and selective NK-2 tachykinin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBC6472V
041M1696V
041M1696
069K1725
074K11452

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William G Paterson et al.
Gut, 56(10), 1347-1352 (2007-05-26)
Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the pathophysiology of oesophageal pain syndromes and hiatus hernia formation. The aim of the current study was to
L Bartho et al.
British journal of pharmacology, 105(4), 805-810 (1992-04-01)
1. The effect of newly developed, receptor-selective tachykinin antagonists (GR 71,251 for NK1 receptors, MEN 10,376 and L 659,877 for NK2 receptors) on noncholinergic transmission to the circular muscle of the guinea-pig ileum has been investigated. 2. In circular muscle
B Bianchi et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 12(1), 6-10 (1999-04-03)
Radioligand binding experiments were performed with crude homogenates from normal human skin in order to investigate substance P receptor density. Binding of [3H]substance P ([3H]SP) reached equilibrium after 20 min and was saturable analysis of saturation curves gave a significantly
O Löfgren et al.
Burns : journal of the International Society for Burn Injuries, 25(2), 125-129 (1999-04-20)
Recent studies have proposed that activation of the sensory nervous system after thermal injury induces the release of vasoactive neuropeptides, including tachykinins which contribute to the local inflammatory reaction as well as to the nociceptive transmission at the spinal cord
Koichi Tan-No et al.
Brain research, 952(1), 7-14 (2002-10-05)
Intrathecal (i.t.) administration of big dynorphin (1-10 fmol), a prodynorphin-derived peptide consisting of dynorphin A and dynorphin B, to mice produced a characteristic behavioral response, the biting and/or licking of the hindpaw and the tail along with slight hindlimb scratching
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