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Safety Information

G2044

Sigma-Aldrich

Glucagon

synthetic, powder, suitable for cell culture

Synonym(s):

GlucaGen, Glucagon peptide

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100 EA
CN¥6,144.32

CN¥6,144.32

Estimated to ship onApril 27, 2025Details

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100 EA
CN¥6,144.32

About This Item

Empirical Formula (Hill Notation):
C153H225N43O49S
CAS Number:
16941-32-5
Molecular Weight:
3482.75
MDL number:
MFCD00167532
UNSPSC Code:
12352209
PubChem Substance ID:
24895084
NACRES:
NA.77
biological source:
synthetic
form:
powder

CN¥6,144.32

Estimated to ship onApril 27, 2025Details

Request a Bulk Order

biological source

synthetic

Quality Level

200

Assay

≥95% (HPLC)

form

powder

potency

0.3-10 μg/mL

technique(s)

cell culture | mammalian: suitable

solubility

0.05 M acetic acid: 1 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

2-8°C

SMILES string

Cl[H].[H]N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C(C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc6c[nH]c7ccccc67)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)O)C(O)=O

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Show Differences

1 of 4

This Item
C4767PHR1439C4930
β-Cyclodextrin powder, BioReagent, suitable for cell culture, ≥97%

C4805

β-Cyclodextrin

β-Cyclodextrin ≥97%

C4767

β-Cyclodextrin

Beta-Cyclodextrin Pharmaceutical Secondary Standard; Certified Reference Material

PHR1439

Beta-Cyclodextrin

γ-Cyclodextrin powder, BioReagent, suitable for cell culture, ≥98%

C4930

γ-Cyclodextrin

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

cell culture | mammalian: suitable

sterility

non-sterile

sterility

-

sterility

-

sterility

-

shipped in

ambient

shipped in

-

shipped in

-

shipped in

ambient

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

room temp

solubility

1 M NaOH: 50 mg/mL

solubility

1 M NH4OH: 50 mg/mL

solubility

-

solubility

1 M NaOH: 25 mg/mL, clear to slightly hazy

Amino Acid Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr

General description

Glucagon is a peptide hormone of 29 amino acids secreted by alpha cells in the pancreas. Its release is controlled by hypothalamus when glucose levels in the blood decreases.[1] The C-terminal region of glucagon is crucial for receptor binding.[2]

Application

Glucagon has been used:
  • in the stimulation of human primary hepatocytes for cyclic adenosine monophosphate (cAMP) production[3]
  • for measuring glucagon response in mice[4]
  • to induce gluconeogenic stimuli in primary hepatocytes[5]

Biochem/physiol Actions

Glucagon functions to elevate glucose by activating GCGR in liver mediating the glucose circulation in blood.[6] The hyperglucagonemia elevated levels of glucagon is observed in diabetes[1] and in nonalcoholic fatty liver disease, post gastric bypass surgery and glucagon based tumors.[7]

Components

H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl

Other Notes

This product is a chemically synthesized glucagon qualified for use in cell culture applications.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000434802
0000434796
0000434801
0000434801
0000434796

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Find documentation for the products that you have recently purchased in the Document Library.

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Lipodystrophy due to adipose tissue-specific insulin receptor knockout results in progressive NAFLD
Softic S, et al.
Diabetes, 65(8), 2187-2200 (2016)
Camille Huet et al.
The Journal of biological chemistry, 295(18), 5836-5849 (2020-03-19)
The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations to maintain a proper energy balance in cells. We show here that suckling-weaning and fasting-refeeding transitions in rodents are associated with changes
Fatty acids-stress attenuates gluconeogenesis induction and glucose production in primary hepatocytes
Budick-Harmelin N, et al.
Lipids in Health and Disease, 11(1), 66-66 (2012)
Structure-conformation-activity studies of glucagon and semi-synthetic glucagon analogs
Hruby VJ
Molecular and Cellular Biochemistry, 44(1), 49-64 (1982)
Glucagon receptor antagonism induces increased cholesterol absorption
Guan HP, et al.
Journal of Lipid Research, 56(11), 2183-2195 (2015)
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