Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
All Photos(1)

Key Documents

View All Documentation

F5135

Sigma-Aldrich

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala

collagenase substrate, chromogenic

Synonym(s):

FALGPA, N-[3-(2-Furyl)acryloyl]-L-leucyl-glycyl-L-prolyl-L-alanine

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
CN¥1,297.23
25 MG
CN¥1,544.45

CN¥1,297.23

List PriceCN¥1,729.63Save 25%

Available to ship onApril 27, 2025Details

All Photos(1)

Select a Size

Change View
5 MG
CN¥1,297.23
25 MG
CN¥1,544.45

About This Item

Empirical Formula (Hill Notation):
C23H32N4O7
CAS Number:
78832-65-2
Molecular Weight:
476.52
MDL number:
MFCD00133552
UNSPSC Code:
12352202
PubChem Substance ID:
329799652
NACRES:
NA.32

CN¥1,297.23

List PriceCN¥1,729.63Save 25%

Available to ship onApril 27, 2025Details

Product Name

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala,

Quality Level

200

UniProt accession no.

Q02111

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)\C=C\c1ccco1)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(O)=O

InChI

1S/C23H32N4O7/c1-14(2)12-17(26-19(28)9-8-16-6-5-11-34-16)21(30)24-13-20(29)27-10-4-7-18(27)22(31)25-15(3)23(32)33/h5-6,8-9,11,14-15,17-18H,4,7,10,12-13H2,1-3H3,(H,24,30)(H,25,31)(H,26,28)(H,32,33)/b9-8+/t15-,17-,18-/m0/s1

InChI key

ZLFQNOJSYZSINX-PVJKAEHXSA-N

Gene Information

mouse ... Prkcq(18761)

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
H6278H7904SML1122
PS48 ≥98% (HPLC)

P0022

PS48

4-Hydroxytamoxifen ≥70% Z isomer (remainder primarily E-isomer)

H6278

4-Hydroxytamoxifen

(Z)-4-Hydroxytamoxifen ≥98% Z isomer

H7904

(Z)-4-Hydroxytamoxifen

BTB06584 ≥98% (HPLC)

SML1122

BTB06584

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

protect from light

storage condition

desiccated, protect from light

storage condition

desiccated, protect from light

storage condition

-

solubility

DMSO: >20 mg/mL

solubility

methanol: 10 mg/mL, ethanol: 20 mg/mL (with heating)

solubility

methanol: 10 mg/mL, ethanol: 20 mg/mL (with heating)

solubility

DMSO: 20 mg/mL, clear

Amino Acid Sequence

FA-Leu-Gly-Pro-Ala

General description

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala or FALGPA is a synthetic substance which resemble the primary structure of collagen, and is hydrolyzed by all known collagenases.[1]

Application

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala has been used for use in FALGPA assay performed using GBS (Group B Streptococci) USF704.[2]

Biochem/physiol Actions

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala or FALGPA is hydrolyzed by collagenases and the optimum pH for hydrolysis is 7.4.[1]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

Substrate for collagenase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCM1118
    BCCK4776
    BCCH9650
    BCCG5673
    BCCB9549

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    R Gayatri et al.
    Biochimica et biophysica acta, 1524(2-3), 228-237 (2000-12-13)
    Bacterial collagenase has now been reacted with a select series of Cr(III) complexes and modifications in the activity of chromium-modified collagenase has been deduced from the extent of hydrolysis of (2-furanacryloyl-L-leucyl-glycyl-L-prolyl-L-alanine), FALGPA. A homologous series of Cr(III) complexes with dimeric
    K K Mäkinen et al.
    Medical microbiology and immunology, 185(1), 1-10 (1996-05-01)
    Relatively scant chemical information has been available on the proteinases and peptidases of spirochetes in spite of the association of spirochetes with several serious infections known to plague humans and other animal species. This situation has partly resulted from difficulties
    M S Yu et al.
    Microbiology (Reading, England), 145 ( Pt 1), 143-150 (1999-04-17)
    The prtV gene, encoding a collagenase of Vibrio parahaemolyticus, was expressed in Escherichia coli and purified by affinity chromatography. The transformant E. coli BL21(DE3)(pPRT2) secreted the recombinant PrtV, and the highest enzyme activity was detected in the culture supernatant after
    E Söderling et al.
    Journal of periodontal research, 26(1), 17-23 (1991-01-01)
    Four rough-surfaced (R) and three smooth-surfaced (S) clinical isolates of Capnocytophaga obtained from the subgingival plaque of periodontitis patients were studied for their peptidase and protease profiles. The results were compared with those obtained with C. gingivalis (which has a
    Z E Juarez et al.
    Infection and immunity, 67(1), 271-278 (1998-12-24)
    Streptococcus gordonii is a frequent cause of infective bacterial endocarditis, but its mechanisms of virulence are not well defined. In this study, streptococcal proteases were recovered from spent chemically defined medium (CDM) and fractionated by ammonium sulfate precipitation and by
    View All Related Papers

    Protocols

    Enzymatic Assay of Collagenase (EC 3.4.24.3) using FALGPA (N-(3-[2-Furyl]acryloyl)-Leu-Gly-Pro-Ala)

    To measure collagenase activity, N-(3-[2-Furyl]acryloyl)-Leu-Gly-Pro-Ala is used in a continuous spectrophotometric rate determination at 345 nm. Collagenase hydrolyzes collagen peptide bonds.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service