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P0022

Sigma-Aldrich

PS48

≥98% (HPLC)

Synonym(s):

5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

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5 MG
CN¥1,297.23
25 MG
CN¥1,544.45

CN¥1,297.23

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Available to ship onApril 27, 2025Details

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5 MG
CN¥1,297.23
25 MG
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About This Item

Empirical Formula (Hill Notation):
C17H15ClO2
CAS Number:
1180676-32-7
Molecular Weight:
286.75
MDL number:
MFCD17215962
UNSPSC Code:
12352200
PubChem Substance ID:
329819977
NACRES:
NA.77

CN¥1,297.23

List PriceCN¥1,729.63Save 25%

Available to ship onApril 27, 2025Details

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2

InChI

1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-

InChI key

LLJYFDRQFPQGNY-QINSGFPZSA-N

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Show Differences

1 of 4

This Item
H6278H7904SML1122
PS48 ≥98% (HPLC)

P0022

PS48

4-Hydroxytamoxifen ≥70% Z isomer (remainder primarily E-isomer)

H6278

4-Hydroxytamoxifen

(Z)-4-Hydroxytamoxifen ≥98% Z isomer

H7904

(Z)-4-Hydroxytamoxifen

BTB06584 ≥98% (HPLC)

SML1122

BTB06584

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

protect from light

storage condition

desiccated, protect from light

storage condition

desiccated, protect from light

storage condition

-

solubility

DMSO: >20 mg/mL

solubility

methanol: 10 mg/mL, ethanol: 20 mg/mL (with heating)

solubility

methanol: 10 mg/mL, ethanol: 20 mg/mL (with heating)

solubility

DMSO: 20 mg/mL, clear

Biochem/physiol Actions

PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site.
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000288009
    0000288009
    0000353883
    0000144296
    0000144297

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