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H1384

Sigma-Aldrich

Hypotaurine

≥98% (TLC)

Synonym(s):

2-Aminoethanesulfinic acid

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¥3,012.56

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50 EA
¥3,012.56

About This Item

Empirical Formula (Hill Notation):
C2H7NO2S
CAS Number:
300-84-5
Molecular Weight:
109.15
MDL number:
MFCD00038197
UNSPSC Code:
12352100
PubChem Substance ID:
57654233
NACRES:
NA.22

¥3,012.56

Please contact Customer Service for Availability
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Quality Level

200

Assay

≥98% (TLC)

color

white to off-white

solubility

H2O: 100 mg/mL

SMILES string

NCCS(O)=O

InChI

1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)

InChI key

VVIUBCNYACGLLV-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
F2256F6760FBS25
固红-锌TR盐 Dye content 15 %

368881

固红-锌TR盐

坚牢红 RC 盐

F2256

坚牢红 RC 盐

Fast Red TR盐 1,5-萘二磺酸盐

F6760

Fast Red TR盐 1,5-萘二磺酸盐

固蓝RR盐 Preweighed Capsules

FBS25

固蓝RR盐

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

500

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

−20°C

storage temp.

−20°C

composition

Dye content, 15%

composition

Dye content, ~20%

composition

-

composition

-

λmax

284 nm

λmax

-

λmax

-

λmax

-

ε (extinction coefficient)

≥3000 at 281-287 nm in water at 0.006 g/L

ε (extinction coefficient)

-

ε (extinction coefficient)

-

ε (extinction coefficient)

-

Application

Hypotaurine has been used as a supplement in fertilization medium (Fert- tyrode albumin lactate pyruvate (TALP)), which used in in-vitro fertilization and evaluation of embryo development.[1][2] It is also used as a H2S scavenger.[3]

Biochem/physiol Actions

Antioxidant that binds hydroxyl radicals. Endogenous inhibitory neuromodulator that is blocked by strychnine and picrotoxin. Inhibits the Na2+-dependent transport of GABA and β-alanine. It is a degradation product of cysteine and a precursor of taurine.
Hypotaurine, a cystamine analog[4], is the precursor for taurine synthesis.[5] It can act as an antioxidant and singlet oxygen scavenger, thereby protecting cells from oxidative damage.[6][7] Hypotaurine is reported to play an important role in the maintenance and stimulation of sperm motility and also in vitro fertilization and embryo development.[8]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000435332
0000435332
0000428898
0000428893
0000428893

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Keiji Mochida et al.
PloS one, 8(1), e49316-e49316 (2013-01-24)
Procedures for cryopreserving embryos vary considerably, each having its specific advantages and disadvantages in terms of technical feasibility, embryo survival yield, temperature permissibility and species- or strain-dependent applicability. Here we report a high osmolality vitrification (HOV) method that is advantageous
The antioxidant action of taurine, hypotaurine and their metabolic precursors.
Aruoma OI
The Biochemical Journal, 256(1), 251-251 (1988)
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.
Hoffstrom BG
Nature Chemical Biology, 6(12), 900-900 (2010)
Improvement of bovine semen quality by removal of membrane-damaged sperm cells with DNA aptamers and magnetic nanoparticles.
Farini V L, et al.
Journal of Biotechnology, 229 , 33-41 (2016)
Hypotaurine protection on cell damage by singlet oxygen.
Pitari G
Taurine 4, 157-162 (2002)
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