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E9156

Sigma-Aldrich

Encainide hydrochloride

≥98% (HPLC), powder

Synonym(s):

(+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide hydrochloride, MJ-9067

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About This Item

Empirical Formula (Hill Notation):
C22H28N2O2 · HCl
CAS Number:
66794-74-9
Molecular Weight:
388.93
MDL number:
MFCD01667688
UNSPSC Code:
12352200
PubChem Substance ID:
329799083
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

solubility

H2O: >25 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl.COc1ccc(cc1)C(=O)Nc2ccccc2CCC3CCCCN3C

InChI

1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H

InChI key

OJIIZIWOLTYOBS-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Biochem/physiol Actions

Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
018K46111
018K4611

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S C Krishnan et al.
Journal of cardiovascular electrophysiology, 9(11), 1167-1172 (1998-12-03)
Three patients in whom Class IC sodium channel blockers induced ST segment elevation in leads V1 through V3 are described. The underlying electrophysiologic mechanism, implications for drug-induced proarrhythmia, and the relationship of the finding to the Brugada syndrome type of
A Hallstrom et al.
Journal of the American College of Cardiology, 25(6), 1250-1257 (1995-05-01)
We studied the relations between heart failure, ejection fraction, arrhythmia suppression and mortality. Both left ventricular ejection fraction and functional class of heart failure are strongly associated with mortality after acute myocardial infarction. Both are also related to the presence
J E Tisdale et al.
Journal of clinical pharmacology, 33(7), 623-630 (1993-07-01)
The efficacy of class 1C antiarrhythmic agents was determined in 36 patients with inducible sustained monomorphic ventricular tachycardia during baseline electrophysiology study (EPS), who continued to have inducible monomorphic ventricular tachycardia during EPS on class 1A antiarrhythmic therapy. Of 12
D Obias-Manno et al.
Annals of epidemiology, 6(2), 93-101 (1996-03-01)
Patient adherence to therapy is essential to assess treatment efficacy, particularly in clinical trials. Active treatment usually is expected to benefit patients. The healthy adherer effect, the association or greater adherence to all health-promoting behaviors, including medication and overall concern
S Goldstein et al.
Circulation, 91(1), 79-83 (1995-01-01)
We tested the hypothesis that patients whose ventricular arrhythmias are easy to suppress have a lower rate of arrhythmic death, defined as arrhythmic death and nonfatal cardiac arrest, the primary end point in the Cardiac Arrhythmia Suppression Trials (CAST-I and
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Articles

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

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