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85558

Sigma-Aldrich

Spermidine

BioUltra, Molecular Biology, ≥99.5% (GC)

Synonym(s):

SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

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¥1,808.60
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¥6,324.87

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1 G
¥1,808.60
5 G
¥6,324.87

About This Item

Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS Number:
124-20-9
Molecular Weight:
145.25
Beilstein:
1698591
EC Number:
204-689-0
MDL number:
MFCD00008229
UNSPSC Code:
12352116
PubChem Substance ID:
57653053
NACRES:
NA.26

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Molecular Biology

Quality Level

200

product line

BioUltra

Assay

≥99.5% (GC)

storage condition

(Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)

technique(s)

ChIP: suitable
buffer exchange: suitable

impurities

DNases, none detected
 RNases, none detected
 insoluble matter, passes filter test
 phosphatases, none detected
 proteases, none detected

refractive index

n20/D 1.479 (lit.)

pH

12.0-13.5 (25 °C, 1 M in H2O)

solubility

H2O: 1 M at 20 °C, clear, colorless

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Show Differences

1 of 4

This Item
H9039MBD00523741
氯化高铁血红素 BioXtra, from Porcine, ≥96.0% (HPLC)

51280

氯化高铁血红素

氯化高铁血红素 from bovine, ≥90%

H9039

氯化高铁血红素

Hemin solution Ready-made microbial growth medium supplement, 0.5 g/L

MBD0052

Hemin solution

氯化血红素 Iron-containing compound of porcine origin that can induce hydrogen peroxide-dependent lipid peroxidation. Reported to increase the number and size of myotubes and the frequency of myotube contractions.

3741

氯化血红素

biological source

Porcine

biological source

bovine

biological source

-

biological source

-

assay

≥96.0% (HPLC)

assay

≥90%

assay

-

assay

-

technique(s)

tissue culture: suitable, transfection: suitable

technique(s)

toxicology assay: suitable

technique(s)

-

technique(s)

-

form

powder or crystals

form

powder

form

liquid

form

solid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

15-25°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

General description

Spermidine is a polyamine[1] and a trivalent organic cation.[2]Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.

Application

Spermidine has been used:
  • as a component of chromosome isolation buffer[3][4]
  • as a component of transcription buffer[5]
  • as a component of homogenization buffer[6]

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.[1]

Features and Benefits

  • Versatile and adaptable for a wide variety of laboratory and research applications
  • Suitable for Molecular Biology and Biochemical research
  • Free from DNase, RNase, NICKase, and protease
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
  • Tested for trace levels of Anions and Cations

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Analysis Note

liquid or solid

Other Notes

For additional information on our range of Biochemicals, please complete this form.
In first strand cDNA synthesis[7]; Effect on endonuclease inhibition by agarose contaminants[8]

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

233.6 °F - closed cup

Flash Point(C)

112 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCK1724
    BCCK3571
    BCCJ7908
    BCCJ8414
    BCCK3893

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    1. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    2. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    3. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    4. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    5. Is this a spermidine solution or a neat liquid, and what is the concentration?

      Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.

    6. My question is not addressed here, how can I contact Technical Service for assistance?

      Ask a Scientist here.

    Foundations of identifying individual chromosomes by imaging flow cytometry with applications in radiation biodosimetry
    Beaton-GLA, et al.
    Methods, 18-24 (2017)
    Restriction Endonucleases and Modification Methylases
    Enzymology Primer for Recombinant DNA Technology, 233-306 (1996)
    Biochemical Isolation of Myonuclei from Mouse Skeletal Muscle Tissue
    Cutler AA, et al.
    Bio-protocol, 7(24) (2017)
    Peptide nucleic acid (PNA) fluorescent in situ hybridization (FISH) on chromosomes in suspension for analysis of repetitive DNA by flow cytometry
    Brind AJ and Lansdorp PM
    Protocol Exchange (2011)
    The effect of spermidine on endonuclease inhibition by agarose contaminants.
    J P Bouché
    Analytical biochemistry, 115(1), 42-45 (1981-07-15)
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