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Safety Information

50240

Sigma-Aldrich

Gly-Gly-Gly

≥98.5% (NT)

Synonym(s):

Glycyl-glycyl-glycine, Triglycine

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About This Item

Linear Formula:
NH2CH2CONHCH2CONHCH2COOH
CAS Number:
Molecular Weight:
189.17
Beilstein:
1711130
MDL number:
UNSPSC Code:
12352200

Assay

≥98.5% (NT)

ign. residue

≤0.1% (as SO4)

loss

≤1% loss on drying, 110 °C

solubility

H2O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

NCC(=O)NCC(=O)NCC(O)=O

InChI

1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)

InChI key

XKUKSGPZAADMRA-UHFFFAOYSA-N

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Amino Acid Sequence

Gly-Gly-Gly

Biochem/physiol Actions

Gly-Gly-Gly may be used for studies on peptide binding and trans-membrane flux; aminopeptidase specificity studies and in the development of new bifunctional chelators. Gly-Gly-Gly is an ideal substrate for reproducible serum protein measurements by the biuret reaction.
Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.

replaced by

Product No.
Description
Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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D T Thwaites et al.
British journal of pharmacology, 113(3), 1050-1056 (1994-11-01)
1. pH-dependent transepithelial transport and intracellular accumulation of the hydrolysis-resistant dipeptide glycylsarcosine (Gly-Sar) have been demonstrated in the model human intestinal epithelial cell line, Caco-2. 2. Experiments with BCECF (2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein)-loaded Caco-2 cells demonstrated that dipeptide (Gly-Sar) transport across the apical
T Terada et al.
American journal of physiology. Renal physiology, 279(5), F851-F857 (2000-10-29)
We examined the peptide transport activity in renal basolateral membranes. [(14)C]glycylsarcosine (Gly-Sar) uptake in rat renal cortical slices was saturable and inhibited by excess dipeptide and aminocephalosporin cefadroxil. When several renal cell lines were screened for the basolateral peptide transport
A. Jamai et al.
Plant physiology, 106(3), 1023-1031 (1994-11-01)
The transport of [14C]glycyl-glycine (Gly-Gly) has been characterized in leaf discs from mature exporting leaves of broad bean (Vicia faba L.). In terms of glycine (Gly) equivalents, the rate of transport of Gly-Gly was similar to that of Gly uptake.
F Chang et al.
Cancer, 80(12 Suppl), 2347-2353 (1997-12-24)
The development of a simple route for the synthesis of the N-hydroxysuccinimide (NHS) ester of S-acetyl-protected mercaptoacetyltriglycine (MAG3) has opened the possibility of preparing novel bifunctional N3S chelators for technetium-99m (99mTc) and other radionuclides. In particular, the synthesis may be
S Frølund et al.
British journal of pharmacology, 161(3), 589-600 (2010-10-01)
BACKGROUND AND PURPOSE The intestinal proton-coupled amino acid transporter, SLC36A1, transports zwitterionic α-amino acids and drugs such as vigabatrin, gaboxadol and δ-aminolevulinic acid. We hypothesize that SLC36A1 might also transport some dipeptides. The aim of the present study was to

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